619-28-3

Usage

InChI:InChI=1/C7H5Cl2NO2/c8-7(9)5-2-1-3-6(4-5)10(11)12/h1-4,7H

Upstream product

• 99-08-1 1-methyl-3-nitrobenzene 
• 99-61-6 3-nitro-benzaldehyde 
• 7647-01-0 hydrogenchloride 
• 86119-84-8 phosphoric acid 
• 10025-87-3 trichlorophosphate 
• 10026-13-8 phosphorus pentachloride 
• 98-87-3 benzylidene dichloride 
• 2243-80-3 3-nitrobenzophenone 
• 791-28-6 Triphenylphosphine oxide 
• 3718-22-7 3-nitrobenzaldehyde hydrazone 
• 62673-14-7 trimethyl(3-nitrobenzyloxy)silane 
• 18483-95-9 2-<3-Nitro-benzyloxy>-tetrahydro-pyran 
• 100-52-7 benzaldehyde 
• 290365-80-9 bis-(α-chloro-3-nitro-benzyl)-ether 

Downstream Products

• 62006-53-5 3,3'-dinitro-trans-stilbene 
• 99-61-6 3-nitro-benzaldehyde 
• 72949-60-1 1-(1-Methyl-1-nitro-ethyl)-2-(2-methyl-propenyl)-4-nitro-benzene 
• 72949-61-2 1-(1-Methyl-1-nitro-ethyl)-4-(2-methyl-propenyl)-2-nitro-benzene 
• 26029-52-7 m-benzotrifluoride 
• 29848-59-7 1-bromo-3-difluoromethyl-benzene 
• 368-99-0 3-difluoromethyl-phenylamine 
• 108-44-1 1-amino-3-methylbenzene 
• 403-25-8 1-(difluoromethyl)-3-nitrobenzene 
• 861349-20-4 1-ethoxy-4-ethoxymethyl-2-nitro-benzene 
• 59907-63-0 1-methoxy-2-methoxymethyl-4-nitro-benzene 
• 876494-02-9 1-methoxy-4-methoxymethyl-2-nitro-benzene 
• 21911-67-1 N-(m-methylphenyl)glycine 

Relevant academic research and scientific papers

One-pot, oxidative and selective conversion of benzylic silyl and tetrahydropyranyl ethers to gem-dichlorides using trichloroisocyanuric acid and triphenylphosphine as an efficient and neutral system

A one-pot and oxidative method is described for the first time for the conversion of benzylic trimethylsilyl (TMS) and tetrahydropyranyl (THP) ethers to gem-dichlorides using trichloroisocyanuric acid (TCCA) and triphenylphosphine (PPh3) in neutral media. Various theses substrates containing electron withdrawing or donating groups can be efficiently converted to their corresponding gem-dichlorides in good to excellent yields. The present method shows a high degree of chemoselectivity, and due to its one-pot nature is in accordance with green chemistry.

Halogenation through Deoxygenation of Alcohols and Aldehydes

An efficient reagent system, Ph3P/XCH2CH2X (X = Cl, Br, or I), was very effective for the deoxygenative halogenation (including fluorination) of alcohols (including tertiary alcohols) and aldehydes. The easily available 1,2-dihaloethanes were used as key reagents and halogen sources. The use of (EtO)3P instead of Ph3P could also realize deoxy-halogenation, allowing for a convenient purification process, as the byproduct (EtO)3Pa?O could be removed by aqueous washing. The mild reaction conditions, wide substrate scope, and wide availability of 1,2-dihaloethanes make this protocol attractive for the synthesis of halogenated compounds.

Synthesis of Aryldihalomethanes by Denitrogenative Dihalogenation of Benzaldehyde Hydrazones

We report a denitrogenative dihalogenation reaction of phenyldiazomethanes in which the hypervalent iodine reagents PhICl2 and TolIF2 act as surrogates for elemental chlorine and fluorine. Halogen transfer from iodane to aryldiazomethane is described, as is a tandem oxidative dihalogenation reaction between iodane and hydrazone. This is the first use of non-α-stabilized diazo compounds in this reaction, which provided an efficient synthesis of aryldifluoromethane (ArCHF2) and aryldichloromethane (ArCHCl2) derivatives. (Figure presented.).

Diverse acetals from stoichiometric amounts of aldehydes and alcohols under very mild conditions: A new twist to PPh3-CCl4 reagent combination

The most frequently utilized method for the preparation of acetals is the reaction of alcohols and aldehydes or ketones, but it suffers from a number of shortcomings: bad thermodynamics, the presence of an acid catalyst and occasionally a complicated reac

One-pot, selective and mild conversion of benzylic alcohols to gem -dichlorides using chlorodiphenylphosphine and 2,3-dichloro-5,6-dicyanobenzoquinone as a new and neutral system

A mild and one-pot conversion of benzylic alcohols to their corresponding gem-dichlorides is reported for the first time using chlorodiphenylphosphine (ClPPh2) and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in dichloromethane under neutral conditions and at room temperature. The present method can be efficiently used for preparation of gem-dichlorides even in the presence of some other functional groups with excellent chemoselectivity.

Facile conversion of aldehydes and ketones to gem-dichlorides using chlorodiphenylphosphine/N-chlorosuccinimide as a new and neutral system

Aldehydes and ketones are easily converted to their corresponding gem-dichlorides using a mixture of chlorodiphenylphosphine and N-chlorosuccinimide (ClPPh2/NCS) in dichloromethane under neutral conditions and at room temperature. Copyright Taylor & Francis Group, LLC.

Conversion of aromatic aldehydes to gem-dichlorides using boron trichloride. A new highly efficient method for preparing dichloroarylmethanes

The chlorination of aromatic aldehydes with boron trichloride in hexane under reflux conditions produces the corresponding dichloromethyl derivatives in excellent yields. (C) 2000 Elsevier Science Ltd.

New applications of tungsten hexachloride (WCl6) in organic synthesis. Halo-de-hydroxylation and dihalo-de-oxo-bisubstitution reactions

Tungsten hexachloride (WCl6) has been used for the halo-de-hydroxylation and dihalo-de-oxo-bisubstitution reactions of benzylic alcohols, benzaldehydes, acyloins, and epoxides to their chlorides, gem-dichlorides, vic-trichlorides, and vic-dichlorides respectively.

Process for preparing geminal dihalides

Geminal dihalides are prepared by reacting a non-enolizable aldehyde and/or ketone with phosgene or thionyl chloride in the presence of an organyl-phosphorus compound of 3-valent and/or 5-valent phosphorus.