2987-05-5

Basic information

• Product Name: 4-(METHYLAMINO)CYCLOHEXANOL
• Synonyms: 4-(METHYLAMINO)CYCLOHEXANOL
• CAS NO: 2987-05-5
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.12
• Mol File: 2987-05-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 211.75 °C at 760 mmHg
• Flash Point: 86.788 °C
• Appearance: /
• Density: 0.977 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-(METHYLAMINO)CYCLOHEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(METHYLAMINO)CYCLOHEXANOL(2987-05-5)
• EPA Substance Registry System: 4-(METHYLAMINO)CYCLOHEXANOL(2987-05-5)

Safety Data

• Hazardous Substances Data: 2987-05-5(Hazardous Substances Data)

Usage

General Description

4-(Methylamino)cyclohexanol is a chemical compound that is categorized as an organic compound. It is also known as 4-MAC. 4-(METHYLAMINO)CYCLOHEXANOL belongs to the cyclohexanols chemical class, which consists of compounds featuring a cyclohexane substituted by one or more hydroxy groups. The structure of 4-(methylamino)cyclohexanol is composed of a cyclohexanol ring with a methylamino functional group at the fourth position. 4-(METHYLAMINO)CYCLOHEXANOL has a broad range of applications in chemical and pharmaceutical industries due to its physiochemical properties. However, it should be handled with care as it may present certain hazardous risks. It is also crucial that its impact and potentially deleterious effects on health and the environment be evaluated.

Upstream product

• 6850-65-3 p-hydroxycyclohexylamine 
• 13482-22-9 4-hydroxycyclohexanone 
• 593-51-1 methylamine hydrochloride 
• 74-89-5 methylamine 
• 150-75-4 N-methyl-p-aminophenol 
• 224309-64-2 tert-butyl N-(4-hydroxycyclohexyl)carbamate 
• 7732-18-5 water 
• 22906-85-0 4-methylamino-phenol; hydrochloride 

Downstream Products

• 60481-81-4 4-(N-methylbenzamido)-cyclohexanol 

Relevant articles and documents

LIPID NANOPARTICLE COMPOSITION

Provided herein are lipids that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination.

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.

NOVEL CARBOSTYRIL DERIVATIVES

Novel carbostyril derivatives having platelet aggregation inhibitory action, antiinflamatory action, antiulcer action, vasodilatory action and phosphodiesterase inhibitory action and are useful for preventing or curing thrombus, arteriosclerosis, hypertension, asthma and other like diseases, and also useful as an antiinflamatory or anti-ulcer agent, represented by the formula wherein R1 is hydrogen, C1-4 alkyl, C2-4 alkenyl, phenyl-C1-4 alkyl-; R2 is hydrogen, a halogen atom, hydroxy, phenyl-C1-4 alkoxy; R3 is hydrogen, hydroxy, C1-4 alkyl; R4 is C3-8 cycloalkyl, substituted or unsubstituted phenyl, C3-8 cycloalkyl-C1-4 alkyl, 2-(3,4-dimethoxyphenyl)-ethyl, R5 is hydrogen, C1-8 alkyl, C2-4 alkenyl, phenyl, C3-8 cycloalkyl, phenyl-C1-4 alkyl, C3-8 cycloalkyl-C1-4 alkyl, m is an integer of 1 - 3, l and n which may be same or different, and are respectively 0 or an integer of 1 - 7 and the sum of l and n is not exceeding 7, the carbon-carbon bond at 3- and 4-positions in the carbostyril skelton is either single or double bond