2987-42-0Relevant academic research and scientific papers
Copper-catalyzed ortho-halogenation of protected anilines
Urones, Beatriz,Martinez, Angel Manu,Rodriguez, Nuria,Arrayas, Ramon Gomez,Carretero, Juan C.
, p. 11044 - 11046 (2013)
A practical Cu-catalyzed direct ortho-halogenation of anilines under aerobic conditions has been developed. The reaction shows typically excellent mono-substitution selectivity, high ortho-regiocontrol and large functional group tolerance.
Palladium-catalyzed oxidative cyclization of N-aryl enamines: From anilines to indoles
Wuertz, Sebastian,Rakshit, Souvik,Neumann, Julia J.,Droege, Thomas,Glorius, Frank
supporting information; experimental part, p. 7230 - 7233 (2009/04/10)
(Chemical Equation Presented) The special advantage of the title reaction to form substituted indoles 2 lies within the broad scope of the transformation: A multitude of N-aryl enaminones 1 can be prepared readily in one step from commercially available anilines. Furthermore, anilines can be converted directly in a one-pot process into the indole products. R1 = H, Me, OMe, Cl, F, carbonyl functionality, CN, fused aryl; R2 = alkyl, aryl; R 3 = alkyl, O-alkyl.
