2-dideuterioaminobromobenzene

Base Information

• Chemical Name: 2-dideuterioaminobromobenzene
• CAS No.: 2987-42-0
• Molecular Formula: C₆H₆BrN
• Molecular Weight: 174.008
• Mol file: 2987-42-0.mol

Synonyms:2-dideuterioaminobromobenzene

Chemical Property of 2-dideuterioaminobromobenzene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-dideuterioaminobromobenzene

There total 1 articles about 2-dideuterioaminobromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoaniline (615-36-1) → 2-dideuterioaminobromobenzene (2987-42-0)

Guidance literature:

With water-d2; In diethyl ether;

DOI:10.1002/anie.200802482

Reference yield:

2-dideuterioaminobromobenzene (2987-42-0) → o-chloroaniline (95-51-2)

Guidance literature:

Multi-step reaction with 4 steps

1: zinc; deuteriated sodium hydroxide / water-d2 / 72 h / Reflux

2: pyridine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: N-chloro-succinimide; oxygen; copper dichloride / acetonitrile / 1 h / 100 °C / 760.05 Torr

4: magnesium / methanol / 20 °C / Sonication

With pyridine; N-chloro-succinimide; deuteriated sodium hydroxide; oxygen; magnesium; copper dichloride; zinc; In tetrahydrofuran; methanol; water-d2; acetonitrile;

DOI:10.1039/c3cc47174h

Reference yield:

2-dideuterioaminobromobenzene (2987-42-0) → C6H4(2)H3N

Guidance literature:

With 10% Pd/C; water-d2; triethylamine; deuterium; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.1002/anie.200802482

upstream raw materials:

2-bromoaniline

Downstream raw materials:

1-bromo-2-deuterobenzene

o-chloroaniline

Refernces

• 1、 Wuertz, Sebastian,Rakshit, Souvik,Neumann, Julia J.,Droege, Thomas,Glorius, Frank. "Palladium-catalyzed oxidative cyclization of N-aryl enamines: From anilines to indoles". supporting information; experimental part. p. 7230 - 7233. Retrieved 2009/04/10.