298704-91-3

Upstream product

• 640-68-6 D-Val-OH 
• 298704-77-5 (R)-tert-butyl 3-methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-ylcarbamate 
• 213619-61-5 N-1-[(1R)-1-benzoyl-2-methylpropyl]-(2S)-2-(N-Boc-amino)propanamide 
• 190260-93-6 (2R)-N-Boc-2-amino-3-methyl-1-phenyl-1-butanone 
• 298704-75-3 N²-(tert-butoxycarbonyl)-N,N-dimethyl-D-valinamide 
• 22838-58-0 Boc-D-Val-OH 
• 50-00-0 formaldehyd 
• 213619-60-4 (3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone 

Downstream Products

• 3398-40-1 (S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid 
• 3398-40-1 (R)-(-)-2-methylserine 

Relevant academic research and scientific papers

Asymmetric synthesis of α-Methyl α-Amino Acids through diastereoselective alkylation under mild reaction conditions of an iminic alanine template with a 1,2,3,6-Tetrahydro-2-Pyrazinone structure

(6R)-6-Isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone, obtained from (R)-valine and (S)-alanine, is highly diastereoselectively alkylated at room temperature by: a) activated alkyl halides under solid-liquid PTC conditions, b) non-activated alkyl halides with organic bases, c) electrophilic olefins employing both solid-liquid PTC conditions and organic bases, and d) allylic carbonates by means of palladium catalysis under neutral conditions. Enantiomerically pure (S)-α-methyl α-amino acids 8 are obtained by hydrolysis of the alkylated pyrazinones.