29878-31-7

Basic information

• Product Name: 4-methyl-1H-benzotriazole
• Synonyms: 4-methyl-1H-benzotriazole;4-Methylbenzotriazole;4-methyl-1H-1,2,3-benzotriazole;7-Methyl-1H-benzotriazole;4-methyl-2H-benzotriazole;4-Methyl-1H-benzo[d][1,2,3]triazole;1H-Benzotriazole, 4-methyl-;4-Methyl-1H-benzotriazole98%
• CAS NO: 29878-31-7
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.15058
• EINECS: 249-921-1
• Product Categories: Aromatics;Heterocycles;Inhibitors;Isotope Labelled Compounds
• Mol File: 29878-31-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 139-143°C
• Boiling Point: 289.3 °C at 760 mmHg
• Flash Point: 137.4 °C
• Appearance: /
• Density: 1.273 g/cm³
• Storage Temp.: Room temperature.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 8.74±0.40(Predicted)
• BRN: 119183
• CAS DataBase Reference: 4-methyl-1H-benzotriazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-1H-benzotriazole(29878-31-7)
• EPA Substance Registry System: 4-methyl-1H-benzotriazole(29878-31-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22-36-52/53
• Safety Statements: 26-61
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 29878-31-7(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

Different sources of media describe the Uses of 29878-31-7 differently. You can refer to the following data:
1. 4-Methylbenzotriazole is a benzotriazole derivative as corrosion inhibitor.
2. A benzotriazole derivative as corrosion inhibitor.
3. A labelled benzotriazole derivative as corrosion inhibitor.

General Description

4-Methyl-1H-benzotriazole is an additive in formulated aircraft deicing and anti-icing fluids (ADAFs) mixture.

InChI:InChI=1/C7H7N3/c1-5-3-2-4-6-7(5)9-10-8-6/h2-4H,1H3,(H,8,9,10)

Upstream product

• 2687-25-4 3-methyl-1,2-benzenediamine 
• 570-24-1 2-Methyl-6-nitroaniline 
• 624-91-9 methyl nitrite 
• 602-01-7 1-methyl-2,3-dinitrobenzene 

Downstream Products

• 135080-58-9 2-<2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-4-methyl-2H-benzotriazole 
• 135080-59-0 1-<2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7-methyl-1H-benzotriazole 
• 135080-57-8 1-<2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-4-methyl-1H-benzotriazole 

Relevant articles and documents

COMPOUNDS AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR

The present invention provides compounds of Formula (I) shown above and their pharmaceutically acceptable salt, solvates, isomers, or prodrugs, as well as pharmaceutical compositions containing these compounds. Also provided by the invention is a method for treating a disorder mediated by macrophage migration inhibitory factor in a subject, comprising administering to the subject in need thereof a compound or a pharmaceutical composition of this invention.

Preparation method of 4-methyl benzotriazole

The invention relates to a preparation method of 4-methyl benzotriazole. The preparation method comprises the following specific steps: (1) performing column separation of 2,3-diaminotoluene and 3,4-diaminotoluene; (2) in a reactor, reacting the 2,3-diaminotoluene in the step (1) with sodium nitrite; (3) dropwise adding sulfuric acid into the solution obtained in the step (2) and keeping the pH value at 5-6 to generate a large number of crystals; (4) performing liquid removal treatment on the mixture of the crystals and liquid obtained in the step (3); (5) heating the crystals obtained in the step (4) for dehydration; and (6) distilling the crystals obtained in the step (5) to obtain the 4-methyl benzotriazole. The preparation method provided by the invention has the following advantages that the 2,3-diaminotoluene and 3,4-diaminotoluene in the raw materials are separated through column separation, the purity of the raw materials is increased, thus the purity of the product is increased.

Metabolism of 1H-benzotriazolecarboxylic acids in vitro and in vivo

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