29886-68-8Relevant academic research and scientific papers
Lewis acid-promoted site-selective cyanation of phenols
Yang, Wen,Zhang, Wu,Zhao, Wanxiang
supporting information, p. 4604 - 4609 (2020/07/04)
An efficient Lewis acid-promoted site-selective electrophilic cyanation of 3-substituted and 3,4-disubstituted phenols has been developed. The cyanation reactions using MeSCN as the cyanating reagent proceeded efficiently to afford a wide range of 2-hydroxybenzonitriles with high efficiency and excellent regioselectivity. This protocol could provide a practical method for the synthesis and modification of biologically active molecules.
A modified procedure for the palladium catalyzed borylation/Suzuki-Miyaura cross-coupling of aryl and heteroaryl halides utilizing bis-boronic acid
Molander, Gary A.,Trice, Sarah L.J.,Tschaen, Brittany
, p. 5758 - 5764 (2015/08/03)
Abstract A modified Pd-catalyzed method of forming aryl- and heteroarylboron species and a two-step, one-pot borylation/Suzuki-Miyaura cross coupling using the atom economical tetrahydroxydiboron (bis-boronic acid, BBA) is reported. By using ethylene glycol as an additive, the new method results in increased yields, lower BBA loading, faster reaction times, and a broader reaction scope, including previously problematic substrates such as heterocycles.
Scope of the two-step, one-pot palladium-catalyzed borylation/Suzuki cross-coupling reaction utilizing bis-boronic acid
Molander, Gary A.,Trice, Sarah L. J.,Kennedy, Steven M.
, p. 8678 - 8688 (2012/11/07)
The use of bis-boronic acid for the direct synthesis of boronic acids has greatly facilitated the two-step, one-pot borylation/Suzuki cross-coupling reaction between aryl and heteroaryl halides. With use of Buchwald's second-generation XPhos preformed catalyst, high yields of cross-coupled products were obtained for most substrates. The method also allows an efficient two-step, one-pot synthesis, providing access to three distinct cross-coupled products after column chromatography. The method also provides a rapid and convenient route to teraryl compounds.
Rhodium-catalyzed selective C-H activation/olefination of phenol carbamates
Gong, Tian-Jun,Xiao, Bin,Liu, Zhao-Jing,Wan, Jian,Xu, Jun,Luo, Dong-Fen,Fu, Yao,Liu, Lei
supporting information; experimental part, p. 3235 - 3237 (2011/08/22)
Rh(III)-catalyzed ortho C-H activation/olefination of phenol carbamates has been developed. High regioselectivity is observed with a range of phenol carbamates enabling efficient coupling with acrylates and styrenes. This reaction exhibits different react
The Synthesis of Hydroxyphenylthiophenes
Baldwin, Larry J.,Pakray, Sudabeh,Castle, Raymond N.,Lee, Milton L.
, p. 1667 - 1669 (2007/10/02)
The synthesis of the five isomeric methoxyphenylthiophenes is described.The methoxy compounds were hydrolyzed to yield the hydroxyphenylthiophenes.
