108932-40-7Relevant articles and documents
Methods and Compositions to Inhibit Edema Factor and Adenylyl Cyclase
-
, (2009/04/24)
Small molecules and their derivatives are described for the treatment and/or prevention of intestinal fluid loss. Also disclosed are methods of using said molecules and their derivatives to treat and/or prevent conditions associated with increased levels
Synthesis and screening of small molecule inhibitors of anthrax edema factor
Jimenez, Maria Estrella,Bush, Kathryn,Pawlik, Jennifer,Sower, Laurie,Peterson, Johnny W.,Gilbertson, Scott R.
supporting information; experimental part, p. 4215 - 4218 (2009/04/07)
The synthesis and development of a novel class of molecules that inhibit anthrax edema factor, an adenylyl cyclase, is reported. These molecules are derived from the initial discovery that histidine and imidazole adducts of the prostaglandin PGE2 reduce the net secretory response of cholera toxin-challenged mice and act directly on the action of anthrax edema factor, a calmodulin-dependent adenylyl cyclase. The simple enones examined in this letter were prepared by palladium-catalyzed Suzuki reaction.
Two methods for the preparation of 2-cyclohexenones from resin-bound 1,3-cyclohexanedione
Fraley, Mark E.,Rubino, Robert S.
, p. 3365 - 3368 (2007/10/03)
The addition of organolithium or Grignard reagents to viny]ogous ester resin 1 followed by mild hydrolysis of product resins 2 provides 3-alkyl-2-cyclohexenones in high purity (>95%). Alternatively, conversion of 1 to vinyl triflate resin 4 followed by palladium-mediated couplings with aryl boronic acids and hydrolysis furnishes 3-ary]-2-cyclohexenones in lower yield, but exceptional purity.
The Synthesis of Hydroxyphenylthiophenes
Baldwin, Larry J.,Pakray, Sudabeh,Castle, Raymond N.,Lee, Milton L.
, p. 1667 - 1669 (2007/10/02)
The synthesis of the five isomeric methoxyphenylthiophenes is described.The methoxy compounds were hydrolyzed to yield the hydroxyphenylthiophenes.
