2990-05-8Relevant academic research and scientific papers
A Four-Step Synthesis of (±)-γ-Lycorane via Pd0-Catalyzed Double C(sp2)-H/C(sp3)-H Arylation
Rocaboy, Ronan,Dailler, David,Baudoin, Olivier
supporting information, p. 772 - 775 (2018/02/09)
An expedient synthesis of lycorine alkaloids is reported using a palladium(0)-catalyzed double C-X/C-H arylation as the key step. The selectivity of this reaction was controlled through the judicious choice of the two halogen atoms, and its generality was
Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation
Rajan
, p. 287 - 291 (2015/01/30)
2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.
New compounds for inhibiting differentiation of osteoclast and pharmaceutical composition comprising thereof
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Paragraph 0227, (2014/02/16)
New compounds and pharmaceutical compositions comprising active ingredients having inhibition effects on osteoclast differentiation are provided. The pharmaceutical compositions comprising the new compounds can be used as medicines for treating metabolic bone diseases such as bone metastatic cancer, solid cancer bone metastasis, musculoskeletal complication by solid cancer bone metastasis, hypercalcemia by malignant tumor, multiple myeloma, primary bone tumor, osteoporosis, rheumatoid arthritis, osteoarthritis, periodontal disease, inflammatory resorption of alveolar bone, inflammatory resorption of bone, and Paget's disease.
Mesoporous Structured Silica - An improved catalyst for direct amide synthesis and its application to continuous flow processing
Comerford, James W.,Farmer, Thomas J.,MacQuarrie, Duncan J.,Breeden, Simon W.,Clark, James H.
, p. 282 - 293 (2013/01/16)
We recently published details of an effective, reusable and benign heterogeneous amidation catalyst based on thermal treatment of amorphous K60 silica, however the loading of catalyst required was high for some reactions. We report herein our further development of a series of heterogeneous catalysts based on structured silica (SBA) that retain all the green credentials of the previously described amorphous silica, but with increased efficiency. These catalysts were then utilised in continuous flow systems, achieving excellent conversions with dramatically reduced reaction times. ARKAT-USA, Inc.
Clean, reusable and low cost heterogeneous catalyst for amide synthesis
Comerford, James W.,Clark, James H.,MacQuarrie, Duncan J.,Breeden, Simon W.
supporting information; experimental part, p. 2562 - 2564 (2009/10/16)
We have developed a heterogeneous silica catalyst that can effectively catalyse amide synthesis from acid and amine, without production of toxic by-products and with the advantage of being readily available, low cost, environmentally benign and reusable. The Royal Society of Chemistry 2009.
Photoinduced Cyclizations of Mono- and Dianions of N-Acyl-o-chloroanilines and N-Acyl-o-chlorobenzylamines as General Methods for the Synthesis of Oxindoles and 1,4-Dihydro-3(2H)-isoquinolinones
Goehring, R. Richard,Sachdeva, Yesh P.,Pisipati, Jyothi S.,Sleevi, Mark C.,Wolfe, James F.
, p. 435 - 443 (2007/10/02)
Formation of the monoanions of a series of N-acyl-N-alkyl-o-chloroanilines by means of LDA in THF followed by irradiation with near-UV light affords 1,3-dialkyloxindoles in good yields.Similar photoinduced cyclizations of dianions derived from N-acyl-o-chloroanilines leads to 3-alkyloxindoles.Photocyclizations of mono- and dianion prepared from α,β-unsaturated o-haloanilides proceed to form 3-alkylideneoxindoles.Carbanions derived from N-acyl-o-chlorobenzylamines also undergo photoassisted ring closure to afford 1,4-dihydro-3(2H)-isoquinolinones.The influence of near-UV light and the effect of inhibitors implicate a radical-chain mechanism as the major reaction pathway in this convenient new method for oxindole and isoquinolinone synthesis.
