3456-79-9

Basic information

• Product Name: 3-PHENYL-OXINDOLE
• Synonyms: 3-PHENYL-OXINDOLE;1,3-Dihydro-3-phenyl-2H-indole-2-one;3-Phenyl-1H-indol-2(3H)-one;3-phenyl-1,3-dihydroindol-2-one;1,3-dihydro-3-phenyl-2H-Indol-2-one
• CAS NO: 3456-79-9
• Molecular Formula: C₁₄H₁₁NO
• Molecular Weight: 209.24
• Mol File: 3456-79-9.mol
• Article Data: 27

Chemical Properties

• Melting Point: 191 °C
• Boiling Point: 375.9 °C at 760 mmHg
• Flash Point: 224.3 °C
• Appearance: /
• Density: 1.194 g/cm³
• Vapor Pressure: 7.51E-06mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Sparingly, Heated, Sonicated), Methanol (Slightly)
• PKA: 14.26±0.40(Predicted)
• CAS DataBase Reference: 3-PHENYL-OXINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-OXINDOLE(3456-79-9)
• EPA Substance Registry System: 3-PHENYL-OXINDOLE(3456-79-9)

Safety Data

• Hazardous Substances Data: 3456-79-9(Hazardous Substances Data)

Usage

General Description

3-Phenyl-oxindole is a chemical compound that belongs to the oxindole class. It is a heterocyclic compound consisting of a lactam ring with an oxindole moiety and a phenyl group. 3-Phenyl-oxindole has potential biological activities, including anti-inflammatory, antibacterial, and antifungal properties, and has been studied for its therapeutic potential in various medical applications. It is also used as a building block in the synthesis of various pharmaceuticals and other organic compounds. Additionally, 3-phenyl-oxindole has been investigated for its potential role as a ligand in coordination chemistry and catalysis. Overall, 3-phenyl-oxindole is a versatile and multifunctional chemical compound with a wide range of potential applications in the fields of medicine, pharmaceuticals, and chemistry.

InChI:InChI=1/C14H11NO/c16-14-13(10-6-2-1-3-7-10)11-8-4-5-9-12(11)15-14/h1-9,13H,(H,15,16)

Upstream product

• 139018-14-7 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one 
• 64-18-6 formic acid 
• 13209-38-6 (2-aminophenyl)(phenyl)methanol 
• 1504-16-1 3-phenyl-1H-indole 
• 59-48-3 2-oxoindole 
• 100-52-7 benzaldehyde 
• 138344-47-5 (2-tert-Butoxycarbonylamino-phenyl)-phenyl-acetic acid 
• 6596-66-3 1-phenyl-2-phenylacetylhydrazine 
• 4410-33-7 N-phenyl-2-hydroxy-4-phenylacetamide 
• 35438-06-3 diethyl (2-oxoindolin-3-yl) phosphate 
• 71-43-2 benzene 
• 108-86-1 bromobenzene 
• 100-59-4 phenylmagnesium chloride 
• 120-72-9 indole 

Downstream Products

• 88323-50-6 1,3-Bis-morpholin-4-ylmethyl-3-phenyl-1,3-dihydro-indol-2-one 
• 28864-76-8 1,1’,3,3’-tetrahydro-3,3’-diphenyl-2H,2’H-3,3’-biindole-2,2’-dione 
• 1094900-75-0 1-diphenylacetyl-3-phenyloxindole 
• 1161949-53-6 methyl 2-oxo-3-phenylindoline-1-carboxylate 
• 1311958-97-0 N-(9H-fluoren-9-yloxycarbonyl)-3-phenyloxindole 
• 1311959-02-0 C₂₈H₁₈ClNO₃ 
• 1402737-42-1 (R)-3-fluoro-3-phenylindolin-2-one 
• 139018-14-7 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one 
• 1567850-21-8 (R)-tert-butyl 3-phenyl-3-(trifluoromethanesulfenyl)-2-oxoindoline-1-carboxylate 
• 1588428-23-2 C₁₅H₁₀F₃NOS 
• 1567850-19-4 (S)-tert-butyl 3-phenyl-3-(trifluoromethanesulfenyl)-2-oxoindoline-1-carboxylate 

Relevant articles and documents

Electrochemical Umpolung C-H Functionalization of Oxindoles

Herein, we present a general electrochemical method to access unsymmetrical 3,3-disubstituted oxindoles by direct C-H functionalization where the oxindole fragment behaves as an electrophile. This Umpolung approach does not rely on stoichiometric oxidants and proceeds under mild, environmentally benign conditions. Importantly, it enables the functionalization of these scaffolds through C-O, and by extension to C-C or even C-N bond formation.

Synthesis of α-Aryl Oxindoles by Friedel-Crafts Alkylation of Arenes

α-Aryl oxindoles are accessed from isatin via a two-step procedure involving a phospha-Brook rearrangement and a Friedel-Crafts alkylation in a one-pot procedure. The use of 1,1,1,3,3,3-hexafluoro-2-propanol as solvent significantly extended the reaction

Metal-free and regiospecific synthesis of 3-arylindoles

A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ri