2990-31-0Relevant articles and documents
Aryl-aldehyde formation in fungal polyketides: Discovery and characterization of a distinct biosynthetic mechanism
Wang, Meng,Beissner, Mirko,Zhao, Huimin
, p. 257 - 263 (2014)
Aryl-aldehydes are a common feature in fungal polyketides, which are considered to be exclusively generated by the R domain of nonreducing polyketide synthases (NR-PKSs). However, by cloning and heterologous expression of both cryptic NR-PKS and nonribosomal peptide synthase (NRPS)-like genes from Aspergillus terreus in Saccharomyces cerevisiae, we identified a distinct mechanism for aryl-aldehyde formation in which a NRPS-like protein activates and reduces an aryl-acid produced by the accompanying NR-PKS to an aryl-aldehyde. Bioinformatics study indicates that such a mechanism may be widely used throughout the fungi kingdom.
Intermediates in the barnol biosynthesis in Penicillium baarnense
Better,Gatenbeck
, p. 391 - 394 (2007/10/12)
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