29900-75-2Relevant academic research and scientific papers
Cosmetic preservative and application thereof as cosmetic formula component
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Paragraph 0032-0035, (2021/09/01)
The invention relates to the field of preservatives, in particular to a cosmetic preservative which comprises any one of the general I, or two or more compounds, wherein R1 represents H, OH, methyl, methoxy, F, Cl or Br. Herein, R2 is H represented Na by
Rhodium(iii)-catalyzed cascade reactions of benzoic acids with dioxazolones: Discovery of 2,5-substituted benzoxazinones as AIE molecules
Li, Jinbiao,Zhang, Shuaizhong,Lonka, Madhava Reddy,Zhang, Jinquan,Zou, Hongbin
supporting information, p. 11203 - 11206 (2019/09/30)
A rhodium-catalyzed cascade reaction of benzoic acids with 1,4,2-dioxazol-5-ones was studied. The carboxyl group enabled a double C-H amidation followed by further intramolecular cyclization to afford 2,5-substituted benzoxazinones, which exhibited aggregation-induced emission (AIE) properties with a promising excited-state intramolecular proton-transfer (ESIPT) phenomenon.
An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives
Mocci, Rita,De Luca, Lidia,Delogu, Francesco,Porcheddu, Andrea
supporting information, p. 3135 - 3144 (2016/10/09)
An operationally simple, and cost efficient conversion of carboxylic acids into hydroxamic acid derivatives via a high-energy mechanochemical activation is presented. This ball milling methodology was applied to a wide variety of carboxylic acids dramatically improving purification issues associated with this class of molecules, which still remain one of the main bottlenecks of classical methodologies. (Figure presented.).
A facile and rapid preparation of hydroxamic acids by hydroxylaminolysis using DBU as base
Beillard, Audrey,Bhurruth-Alcor, Yushma,Bouix-Peter, Claire,Bouquet, Karinne,Chambon, Sandrine,Clary, Laurence,Harris, Craig S.,Millois, Corinne,Mouis, Grégoire,Ouvry, Gilles,Pierre, Romain,Reitz, Arnaud,Tomas, Loic
supporting information, p. 2165 - 2170 (2016/05/02)
While there are many protocols for the preparation of hydroxamic acids from their corresponding carboxylic acid or carboxylic ester precursors, most use strong mineral bases that can lead to carboxylic acid impurities that can be difficult to remove using standard chromatographic techniques. This problem is exacerbated when the carbonyl group is hindered. Herein, we communicate a robust hydroxylaminolysis protocol for the preparation of hydroxamic acids in high yield and purity.
Dioxazoles, a new mild nitrene transfer reagent in gold catalysis: Highly efficient synthesis of functionalized oxazoles
Chen, Ming,Sun, Ning,Chen, Haoyi,Liu, Yuanhong
supporting information, p. 6324 - 6327 (2016/05/19)
A gold-catalyzed regioselective [3+2] cycloaddition of ynamides with 1,4,2-dioxazoles was developed and offers a novel approach to obtain highly functionalized oxazoles under mild reaction conditions. 1,4,2-Dioxazole was found to act as an efficient N-acyl nitrene equivalent to trigger a facile generation of α-imino gold-carbene intermediate through the elimination of a ketone.
One-pot synthesis of hydroxamic acids from aldehydes and hydroxylamine
Dettori, Giovanna,Gaspa, Silvia,Porcheddu, Andrea,De Luca, Lidia
supporting information, p. 2709 - 2713 (2014/09/17)
A one-pot oxidative transformation of aldehydes into hydroxamic acids by the use of an aqueous solution of hydroxylamine is reported. The methodology gives high yields and makes use of cheap, abundant and easily available reagents.
Synthesis of hydroxamic acids by using the acid labile O-2-methylprenyl protecting group
Nikitjuka, Anna,Jirgensons, Aigars
supporting information, p. 2972 - 2974 (2013/02/22)
Coupling of carboxylic acids with O-2-methylprenyl hydroxylamine provided O-protected hydroxamic acids, which could be deprotected by treatment with trifluoroacetic acid (TFA) in dichloromethane giving volatile by-products. Protected hydroxamic acids could be N-arylated or alkylated followed by deprotection to give N-substituted hydroxamic acids. Georg Thieme Verlag KG · Stuttgart · New York.
METHODS OF REDUCING VIRULENCE IN BACTERIA
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Page/Page column 75; 87, (2011/09/19)
A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising contacting the bacterium with an effective amount of a compound described herein.
Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors
Thaler, Florian,Colombo, Andrea,Mai, Antonello,Amici, Raffaella,Bigogno, Chiara,Boggio, Roberto,Cappa, Anna,Carrara, Simone,Cataudella, Tiziana,Fusar, Fulvia,Gianti, Eleonora,Di Ventimiglia, Samuele Joppolo,Moroni, Maurizio,Munari, Davide,Pain, Gilles,Regalia, Nickolas,Sartori, Luca,Vultaggio, Stefania,Dondio, Giulio,Gagliardi, Stefania,Minucci, Saverio,Mercurio, Ciro,Varasi, Mario
experimental part, p. 822 - 839 (2010/07/05)
The histone deacetylases (HDACs) are able to regulate gene expression, and histone deacetylase inhibitors (HDACi) emerged as a new class of agents in the treatment of cancer as well as other human disorders such as neurodegenerative diseases. In the prese
Synthesis of hydroxamic acids by activation of carboxylic acids with N,N'-carbonyldiimidazole: Exploring the efficiency of the method
Usachova, Natalija,Leitis, Gundars,Jirgensons, Aigars,Kalvinsh, Ivars
experimental part, p. 927 - 935 (2010/05/01)
Activation of carboxylic acids with N,N'-carbonyldiimidazole followed by the reaction with anhydrous or aqueous hydroxylamine hydrochloride was demonstrated to be an operationally simple method for the synthesis of hydroxamic acids in good yield and high purity after aqueous workup. The potential by-product, N,O-diacylhydroxylamine, is cleanly transformed to hydroxamic acid in these reaction conditions.
