33934-11-1Relevant academic research and scientific papers
Asymmetric Syntheses of the Naturally Ocurring β-Amino Acids, β-Lysine, β-Leucine and β-Phenyl-β-alanine via Nitrone Cycloaddition
Keirs, David,Moffat, David,Overton, Karl,Tomanek, Richard
, p. 1041 - 1051 (2007/10/02)
A general asymmetric synthesis of β-amino acids is based on the dipolar cycloaddition of nitrones 7 (R* chiral) with vinyl acetate 8a, ketene acetals 8b or α-chloroacrylonitrile 8c.The cycloadducts 9 are converted either directly (9b) or via the isoxazolidones 10 (9a, 9c) into the free β-amino acids 11.Diastereoselectivity at C-3 in the adducts 9 ranges between 2:1 and 11:1.The natural β-amino acids, β-lysine, β-leucine and β-phenyl-β-alanine, have been prepared in this way.
N,O-HETEROCYCLES. XIX. THE FORMATION OF THE ISOXAZOLIDIN-5-ONE RING FROM CINNAMOHYDROXAMIC ACID DERIVATIVES
Liguori, Angelo,Sindona, Giovanni,Uccella, Nicola
, p. 377 - 380 (2007/10/02)
Cinnamohydroxamic acids have been converted into isoxazolidin-5-ones by conjugate N-methylhydroxylamine addition followed by cyclization, in a one-pot procedure.The same heterocyclic system can be obtained directly from the appropriate acyl chloride deriv
Method for the production of N-alkyl beta-hydroxylamine hydrocinnamonyl hydroxamic acids
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, (2008/06/13)
The subject invention is directed to a method of making compounds having the formula: STR1 wherein R1 is alkyl, R2 is H or alkyl, R3 and R4 are H, halogen, amino, alkylamino, alkoxy, alkyl, OH, O, NO2 or combinations thereof, and X is CH or N, which compounds are useful as antihypertensive agents.
Anti-hypertensive compounds
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, (2008/06/13)
The subject invention is directed to compounds having the formula: STR1 wherein R1 and R2 are H, alkyl or combinations thereof, R3 and R4 are H, halogen, amino, alkylamino, alkoxy, alkyl, OH, O, NO2 or combinations thereof, and X is CH or N, which compounds are useful as anti-hypertensive agents.
