29908-27-8

Upstream product

• 40027-94-9 3-phenyl-1-(2-thienyl)propan-1-one 
• 1003-09-4 2-bromothiophene 
• 206652-10-0 C₆H₅CH₂CH₂CH₂ZnI 
• 4119-41-9 1-iodo-3-phenylpropan 
• 501-52-0 3-Phenylpropionic acid 

Downstream Products

• 136573-23-4 3,3-Dimethyl-5-oxo-5-[5-(3-phenyl-propyl)-thiophen-2-yl]-pentanoic acid 
• 1026074-15-6 3-Methyl-5-oxo-5-[5-(3-phenyl-propyl)-thiophen-2-yl]-pentanoic acid 
• 102473-13-2 2,10-diphenyl-decanoic acid 
• 102599-33-7 2-phenyl-3t-[5-(3-phenyl-propyl)-[2]thienyl]-acrylic acid 
• 111294-75-8 2-phenyl-3c-[5-(3-phenyl-propyl)-[2]thienyl]-acrylonitrile 
• 859794-02-8 5-[3-(4-carboxy-phenyl)-propyl]-thiophene-2-carboxylic acid 
• 26547-51-3 8-phenyloctanoic acid 
• 859491-02-4 5-(3-phenyl-propyl)-thiophene-2-carboxylic acid 
• 142259-79-8 6-<<5-(3-phenylpropyl)-2-thienyl>thio>hexanoic acid sodium salt 
• 142260-07-9 8-<5-(3-phenylpropyl)-2-thienyl>octanoic acid sodium salt 
• 142259-90-3 5-hydroxy-7-<5-(3-phenylpropyl)-2-thienyl>heptanoic acid sodium salt 
• 101336-01-0 5-<5-(3-phenylpropyl)-2-thienyl>pentanoic acid sodium salt 
• 142259-89-0 5-oxo-7-<5-(3-phenylpropyl)-2-thienyl>heptanoic acid ethyl ester 
• 142259-88-9 5-oxo-7-<5-(3-phenylpropyl)-2-thienyl>heptanoic acid 

Relevant academic research and scientific papers

Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling

A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp3)–C(sp2) and C(sp2)–C(sp2) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.

Amino derivatives of phenyl alkyl thiophene as inhibitors of bone resorption. Structure-activity relationship

Metabolism of arachidonic acid through the 5-lipoxygenase (LO) pathway generates compounds that stimulate osteoclastic bone resorption; since LO metabolites might play a role in bone loss due to excessive resorption it was tried to develop a series of antiresorptive agents starting from an already known LO inhibitor. Of the 35 compounds synthesized, 11 strongly inhibited (10 μmol/l) retinoic acid-induced bone resorption in cultured mouse calvariae; they were also tested for their effect on LO activity using rat peritoneal neutrophils, but no correlation could be drawn between inhibition of LO and bone resorption. Other pathways, still to be identified, must therefore be targeted by these compounds even though LO inhibition might contribute to their effects on bone. Two compounds selected for further studies were found active on parathyroid hormone-induced osteolysis, while they had no effect on basal resorption; they must, therefore, act at some key point in the process of activation of osteoclastic resorption. This series of compounds may represent a new way for the treatment of bone loss due to excessive resorption.

Thiophene compounds, compositions and use

1. New thiophene compounds of the formula: STR1 in which: X represents hydrogen, halogen, C1 -C5 alkyl or alkoxy or dialkylamino; n represents 1 or 2; a represents an integer of from 2 to 6; b represents 2 or 3; c represents 1 or 2,