299162-83-7 Usage
Uses
Used in Pharmaceutical Research:
1-(4-FLUOROPHENYL)-5-PHENYL-1H-PYRAZOLE is used as a research compound for the development of new drugs with therapeutic benefits. Its unique structure and functional groups make it a promising candidate for further study in medicinal chemistry.
Used in Medicinal Chemistry:
1-(4-FLUOROPHENYL)-5-PHENYL-1H-PYRAZOLE is used as a building block for the synthesis of new pharmaceutical compounds with potential applications in various therapeutic areas. Its diverse biological activities, such as anti-inflammatory, analgesic, antihypertensive, and antitumor properties, make it a valuable component in the design and development of novel drugs.
Used in Drug Discovery:
1-(4-FLUOROPHENYL)-5-PHENYL-1H-PYRAZOLE is used as a starting material or intermediate in the drug discovery process. Its potential to exhibit a wide range of biological activities makes it a valuable asset in the search for new therapeutic agents with improved efficacy and safety profiles.
Used in Drug Development:
1-(4-FLUOROPHENYL)-5-PHENYL-1H-PYRAZOLE is used as a key component in the development of new drugs with therapeutic benefits. Its unique structure and functional groups allow for the exploration of various chemical modifications and optimization strategies to enhance its pharmacological properties and potential for clinical use.
Check Digit Verification of cas no
The CAS Registry Mumber 299162-83-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,9,1,6 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 299162-83:
(8*2)+(7*9)+(6*9)+(5*1)+(4*6)+(3*2)+(2*8)+(1*3)=187
187 % 10 = 7
So 299162-83-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H11FN2/c16-13-6-8-14(9-7-13)18-15(10-11-17-18)12-4-2-1-3-5-12/h1-11H
299162-83-7Relevant academic research and scientific papers
Copper-mediated tandem ring-opening/cyclization reactions of cyclopropanols with aryldiazonium salts: Synthesis of: N -arylpyrazoles
Liu, Jidan,Xu, Erjie,Jiang, Jinyuan,Huang, Zeng,Zheng, Liyao,Liu, Zhao-Qing
supporting information, p. 2202 - 2205 (2020/02/26)
A general method for the synthesis of structurally diverse N-arylpyrazoles from readily available cyclopropanols and aryldiazonium salts is disclosed. The reaction was conducted at room temperature within minutes with a broad substrate scope and excellent regioselectivity.
A new germanium-based linker for solid phase synthesis of aromatics: Synthesis of a pyrazole library
Spivey, Alan C.,Diaper, Christopher M.,Adams, Harry,Rudge, Andrew J.
, p. 5253 - 5263 (2007/10/03)
An efficient synthesis of chlorogermane linker 12 is described. Economic introduction of germanium into this linker is accomplished by insertion of dichlorogermylene [from germanium(IV) chloride] into the homobenzylic C-Cl bond of 4-(2-chloroethyl)phenol 1. Using linker 12, transmetalation with lithiated 4-acetophenone, 3-acetophenone, and 4-(4'methoxy)biphenyl followed by Mitsunobu-type coupling to Argogel gives functionalized resins 14, 16, and 18, respectively. Treatment of resin 18 with TFA, ICl, Br2, or NCS effects clean ipso-degermylation releasing biphenyls 19-22, respectively. Resins 14 and 16 are employed for the parallel synthesis of a library of pyrazoles by enaminone formation (using Bredereck's reagent), condensative ring-closure (using a series of monosubstituted hydrazines), and cleavage (using TFA and Br2). Analysis of this library reveals the influence of the hydrazine substituent on both the regioselectivity of ring-closure and the propensity for electrophilic substitution at the 4-position of the pyrazoles during ipso-degermylative cleavage.
