299164-48-0Relevant academic research and scientific papers
Design, synthesis and antidiabetic evaluation of oxazolone derivatives
Mariappan,Saha,Datta, Sriparna,Kumar, Deepak,Haldar
, p. 335 - 341 (2012/05/20)
A series of ten novel (2a-j) 4-arylidine 2-[4-methoxy phenyl] oxazol-5-one derivatives were synthesized and assayed in vivo to investigate their antidiabetic activities by streptozotocin-induced model in rat. These derivatives showed considerable biological efficacy when compared to rosiglitazone, a potent and wellknown antidiabetic agent as a reference drug. All the compounds were effective, amongst them 2d shows more prominent activity at 50 mg/k.g.p.o. The experimental results are statistically significant at P 0.01 level. Indian Academy of Sciences.
