299179-24-1Relevant articles and documents
Asymmetrie synthesis of (R)-(-)-baclofen via asymmetric dihydroxylation
Thakur,Paraskar,Sudalai
, p. 326 - 330 (2008/02/09)
A short and efficient asymmetric synthesis of (R)-(-)-baclofen, a selective GABAB agonist has been described with an overall yield of 14% and 85% ee. The Os-catalyzed Sharpless asymmetric dihydroxylation of a,β-unsaturated olefin constitutes the key step in introducing stereogenic centers into the molecule.