299206-73-8Relevant academic research and scientific papers
3-(4-Phenoxyphenyl)pyrazoles: A Novel Class of Sodium Channel Blockers
Yang, Ji,Gharagozloo, Parviz,Yao, Jiangchao,Ilyin, Victor I.,Carter, Richard B.,Nguyen, Phong,Robledo, Silvia,Woodward, Richard M.,Hogenkamp, Derk J.
, p. 1547 - 1552 (2007/10/03)
A series of 3-(4-phenoxyphenyl)-1H-pyrazoles were synthesized and characterized as potent state-dependent sodium channel blockers. A limited SAR study was carried out to delineate the chemical requirements for potency. The results indicate that the distal
Aryl substituted pyrazoles, and pyrroles, and the use thereof
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, (2008/06/13)
This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13are set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
