35114-93-3

Usage

Uses

Used in Pharmaceutical Industry:
1-[4-(4-Fluorophenoxy)phenyl]ethanone is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows it to modulate biological activity, making it a promising candidate for the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry:
1-[4-(4-Fluorophenoxy)phenyl]ethanone is used as a valuable intermediate in the production of complex molecules for medicinal chemistry research. Its ability to modulate biological activity contributes to the discovery and design of novel compounds with potential therapeutic applications.
Used in Drug Design:
1-[4-(4-Fluorophenoxy)phenyl]ethanone is used as a key component in drug design, where its unique structure and properties can be leveraged to create new molecules with specific biological activities. This can lead to the development of innovative treatments for various diseases and conditions.

InChI:InChI=1/C14H11FO2/c1-10(16)11-2-6-13(7-3-11)17-14-8-4-12(15)5-9-14/h2-9H,1H3

Upstream product

• 371-41-5 4-Fluorophenol 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 654681-20-6 (4-fluorophenoxymethyl)-(4-fluorophenyl)-ketone 
• 1765-93-1 4-fluoroboronic acid 
• 99-93-4 4-Hydroxyacetophenone 
• 100-19-6 (4-nitrophenyl)ethanone 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 58727-59-6 3-p-(p-fluorophenoxy)-phenyl-3-hydroxybutyric acid 
• 96201-47-7 2-(4-(4-fluorophenoxy)phenyl)-6-fluoroquinoline-4-carboxylic acid 
• 299206-73-8 3-[4-(4-fluorophenoxy)phenyl]-1H-pyrazole 
• 86431-76-7 4-fluorophenyl 4-(chloroisopropyl)phenyl ether 
• 41073-36-3 4-fluorophenyl 4-(hydroxyisopropyl)phenyl ether 
• 299206-86-3 2-bromo-1-[4-(4-fluorophenoxy)phenyl]ethanone 

Relevant academic research and scientific papers

Copper-in-charcoal (Cu/C) promoted diaryl ether formation

(Chemical Equation Presented) Copper impregnated into charcoal efficiently catalyzes cross-couplings between aryl bromides and phenols. The etherifications were conveniently promoted by microwave heating.

Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry

A hydrogen-transfer strategy for the catalytic functionalization of benzylic alcohols via electronic arene activation, accessing a diverse range of bespoke diaryl ethers and aryl amines in excellent isolated yields (38 examples, 70% average yield), is reported. Taking advantage of the hydrogen-transfer approach, the oxidation level of the functionalized products can be selected by judicious choice of simple and inexpensive additives.

With substituted pyrazine and imidazole derivatives, their preparation and their use in medicine (by machine translation)

The invention discloses a substituted pyrazine and imidazole derivatives, their preparation and their use in medicine. Specifically, the invention relates to a compound of general formula (I) indicated by the new derivative and its pharmaceutically acceptable salt or pharmaceutical composition containing the same, and its preparation method. The invention also discloses the derivative and its pharmaceutically acceptable salt or pharmaceutical composition containing the same in the Bruton tyrosine kinase inhibitors, and in preparing and treating and/or preventing tumor diseases such as inflammation of the application of the medicament. Wherein the general formula (I) of each substituent as defined in the specification. (by machine translation)

Substituted pyridoimidazole derivative and preparation thereof, and applications of substituted pyridoimidazole derivative in medicines

The present invention discloses a substituted pyridoimidazole derivative and preparation thereof, and applications of the substituted pyridoimidazole derivative in medicines, and particularly relates to a new derivative represented by a general formula (I) and a pharmaceutically acceptable salt thereof or a pharmaceutical composition containing the new derivative, and a preparation method of the new derivative. The present invention further discloses applications of the derivative and the pharmaceutically acceptable salt thereof or the pharmaceutical composition containing the new derivative in Bruton tyrosine kinase inhibitors and in preparation of drugs for treatment and/or prevention of tumors, inflammations, and other diseases, wherein each substituent in the general formula (I) is defined in the specification. The formula (I) is defined in the specification.

Derivative with imidazopyridine, preparation method and application in medicine thereof

The invention discloses a derivative with imidazopyridine, a preparation method and application in medicine thereof. Concretely speaking, the invention relates to a novel derivative, medicinal salt of the derivative or pharmaceutical compositions containing the derivative, and the preparation method of the derivative showed in general formula (I). The invention also discloses application of the derivative, medicinal salt of the derivative or pharmaceutical compositions containing the derivative in Bruton tyrosine kinase inhibitor, preparing the medicine for treating or preventing tumor and inflammation diseases. Substituent groups in general formula (I) are identical to definitions in the specification (the structure is shown in the description).

Derivative having imidazopyrazines, preparation method and application thereof of derivative on medicine

The invention discloses a derivative having imidazopyrazines, a preparation method and an application thereof of the derivative on medicine. Concretely speaking, the invention relates to a novel derivative shown in a general formula (I) and its medicinal salt or a pharmaceutical composition containing the derivative, and its preparation method. The invention also discloses the derivative or its medicinal salt or an application of the pharmaceutical composition containing the derivative in a Bruton tyrosine kinase inhibitor, and in preparation of medicines for treating and/or preventing diseases such as tumour and inflammation. The substituent in the formula (I) has same definition in the specification.

Ligand-free copper-catalyzed O-arylation of nitroarenes with phenols

The first example of ligand-free copper-catalyzed O-arylation of nitroarenes with phenols was developed, achieving unsymmetrical diaryl ethers in moderate to excellent yields. This arylation proceeded smoothly without promotion of the ligands, and displayed great functional group compatibility. Thus, the method represents a new, facile, and cost-effective approach to access unsymmetrical diaryl ethers.

Novel imidazole derivatives, their preparation and their use as medicaments

Novel imidazole compounds of the formula wherein the substituents are as defined in the application having antitumoral activity and use thereof.