29927-14-8

Usage

InChI:InChI=1/C7H6N2O3S2/c8-14(11,12)7-9-5-3-4(10)1-2-6(5)13-7/h1-3,10H,(H2,8,11,12)

Upstream product

• 452-35-7 6-ethoxybenzothiazole-2-sulfonamide 
• 86394-94-7 2-sulfamoyl-6-benzothiazolyl 2,2-dimethylpropionate 
• 5304-15-4 6-ethoxy-2-benzothiazolesulfenamide 
• 120-53-6 6-ethoxy-2-mercaptobenzothiazole 

Downstream Products

• 86394-93-6 2-sulfamoyl-6-benzothiazolyl 2-phenylacetate 
• 121811-05-0 2,4,6-Trimethyl-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 121811-03-8 4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 86394-97-0 (E)-3-Phenyl-acrylic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 121811-02-7 4-Dimethylaminomethyl-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 121811-01-6 4-Dimethylamino-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 121811-04-9 2,6-Dimethoxy-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 
• 86395-15-5 2-sulfamoyl-6-benzothiazolyl benzoate 
• 86394-95-8 (2-sulfamoyl-6-benzothiazolyl)2-(4-chlorophenyl) acetate 
• 1071476-61-3 (S)-methyl 2-((S)-2-(4-((2-(N-(bis(4-methoxyphenylxphenyl)methyl)sulfamoyl)benzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-N-(tert-butoxycarbonyl)-3-(4-(2-(tosyloxy)ethoxy)phenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate 
• 1071476-55-5 (S)-ethyl 1-(2-(4-((2-(N-(bis(4-methoxyphenyl)(phenyl)methyl)sulfamoyl)benzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)-3-(4-(2-(tosyloxy)ethoxy)phenyl)propanoyl)piperidine-4-carboxylate 
• 1071476-41-9 (2S)-ethyl 2-(2-(4-((2-(N-(bis(4-methoxyphenyl)(phenyl)methyl)sulfamoyl)benzo[d]thiazol-6-yloxy)methyl)-1H-1,2,3-triazol-1-yl)acetamido)-3-(3-((1-(1-fluoro-3-hydroxypropan-2-yl)-1H-1,2,3-triazol-4-yl)methoxy)benzylthio)propanoate 

Relevant academic research and scientific papers

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

A series of benzene sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors which incorporate lipophilic 4-alkoxy- and 4-aryloxy moieties, together with several derivatives of ethoxzolamide and sulfanilamide are reported. These derivatives were investi

DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

Topically active ocular benzothiazole sulfonamide carbonic anhydrase inhibitors

This invention is directed to compounds of the formula STR1 and pharmaceutically acceptable salts thereof wherein R6 is hydrogen or lower alkyl; each R1 is hydrogen, lower alkyl, halogen, nitro, trihaloalkyl, lower alkoxy, formyl, lower alkanoyl, loweralkylamino or diloweralkylamino STR2 X is O, S or NR5 ; R2 is OR7 or NR7 R8 ; each R3 and R4 are independently hydrogen or lower alkyl; R5 R7 and R8 are independently hydrogen or lower alkyl; n is 0-3 and m is 0-6. These compounds are useful for treating glaucoma or assessing corneal function in mammals.

Topically Active Carbonic Anhydrase Inhibitors. 1. O-Acyl Derivatives of 6-Hydroxybenzothiazole-2-sulfonamide

A series of O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide (4, L-643,799) was prepared and the potential utility of each series member as a topically active inhibitor of ocular carbonic anhydrase was determined.In vitro studies showed these esters to be substrates for ocular esterases which liberate 4 during corneal translocation.The most interesting series member, 2-sulfamoyl-6-benzothiazolyl 2,2-dimethylpropionate (22, L-645,151), acting as a prodrug form of 4, was found to enhance delivery through the isolated albino rabbit cornea by 40-fold when compared to the parent phenol 4.Studies in rabbits revealed that 22 is a potent topically active ocular hypotensive carbonic anhydrase inhibitor.

Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Novel carbonates of 6(or 5)-hydroxy-2-benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.

Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Novel phosphates of 6(or 5)-hydroxy-2-benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.

Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Novel sulfonates of 6(or 5)-hydroxy-2-benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.

Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Novel carbamates of 6(or 5)-hydroxy-2- benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.

Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Novel sulfamates of 6(or 5)-hydroxy-2-benzothiazolesulfonamide are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions include drops and inserts.