29936-68-3Relevant academic research and scientific papers
Diastereo- and enantioselective intramolecular C(sp3)-H arylation for the synthesis of fused cyclopentanes
Martin, Nicolas,Pierre, Cathleen,Davi, Micha?l,Jazzar, Rodolphe,Baudoin, Olivier
experimental part, p. 4480 - 4484 (2012/05/20)
All C-H bonds are not equal: The intramolecular arylation of unactivated C(sp3)-H bonds in the presence of a chiral Pd/binepine catalyst allows the synthesis of fused cyclopentanes efficiently and in an diastereo- and enantioselective manner (see scheme).
Phase transfer alkylation of arylacetonitriles revisited
Barbasiewicz, Micha?,Marciniak, Karolina,Fedoryński, Micha?
, p. 3871 - 3874 (2007/10/03)
Phase transfer alkylations of phenylacetonitrile derivatives carried out in the presence of 60-75% aqueous KOH, instead of the typical 50% NaOH, provide substantial improvements in the overall yields and purity of products. Reactions with simple secondary alkyl halides, as well as cycloalkylations with 1,2- and 1,3-dihaloalkanes proceed with good yields. Increasing the concentration of base diminishes the formation of by-products from competitive β-elimination processes.
