299403-77-3

Upstream product

• 128461-65-4 3-(p-methoxybenzyloxy)propanal 
• 299403-76-2 (2R,3S,6R)-6-Allyl-3-(1-ethoxy-ethoxy)-2-prop-2-ynyl-3,6-dihydro-2H-pyran 

Downstream Products

• 1026611-82-4 {(2R,4aS,6R,9aR)-2-Allyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-4a,6,9,9a-tetrahydro-2H-1,5-dioxa-benzocyclohepten-8-yl}-triethyl-silane 
• 299403-91-1 Benzoic acid (2R,4aS,6R,7S,9aR)-2-allyl-6-((Z)-pent-2-en-4-ynyl)-4a,6,7,9a-tetrahydro-2H-1,5-dioxa-benzocyclohepten-7-yl ester 

Relevant academic research and scientific papers

Acetylene cobalt complex and vinylsilane strategy in the synthesis of ciguatoxin (D)EF analog

A synthetic route to the (D)EF analog of ciguatoxin has been explored through acetylene cobalt complex and vinylsilane strategy. The central reactions in the synthesis are: (i) ether ring formation mediated by acetylene cobalt complex and (ii) decomplexation of the endo-acetylene cobalt complexes to vinylsilanes or olefins. Unusual rearrangement of epoxy-silane to allylic alcohol is also described. (C) 2000 Elsevier Science Ltd.