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Usage

Uses

Used in Pharmaceutical Industry:
1-(2-ETHYL-PHENYL)-1H-PYRROLE is used as a building block for the synthesis of various pharmaceuticals. Its unique molecular structure allows for the creation of a wide range of drugs with different therapeutic applications, contributing to the development of new treatments for various health conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(2-ETHYL-PHENYL)-1H-PYRROLE is utilized as a component in the development of new agrochemicals. Its incorporation into these products can enhance their effectiveness in protecting crops from pests and diseases, thereby increasing agricultural productivity.
Used as an Antifungal Agent:
1-(2-ETHYL-PHENYL)-1H-PYRROLE is used as an antifungal agent due to its potential biological activities. It can be employed in the development of treatments for fungal infections, providing a new avenue for combating these diseases and improving patient outcomes.
Used in the Treatment of Neurodegenerative Diseases:
1-(2-ETHYL-PHENYL)-1H-PYRROLE is also being studied for its potential use in the treatment of neurodegenerative diseases. Its incorporation into new drug formulations could lead to the development of more effective therapies for conditions such as Alzheimer's, Parkinson's, and other related diseases, offering hope for patients and their families.

Upstream product

• 6117-80-2 1,4-butenediol 
• 578-54-1 ortho-ethylaniline 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 

Relevant academic research and scientific papers

Nickel-Catalyzed Synthesis of N-Substituted Pyrroles Using Diols with Aryl- and Alkylamines

Herein, nickel-catalyzed sustainable strategy for the synthesis of N-substituted pyrroles using butene-1,4-diols and butyne-1,4-diols with a series of aryl-, alkyl-, and heteroarylamines is reported. The catalytic protocol is tolerant of free alcohol, halide, alkyl, alkoxy, oxygen heterocycles, activated benzyl, and the pyridine moiety and resulted in up to 90% yield. Initial mechanistic studies involving defined nickel catalyst, determination of rate, and order of reaction including deuterium-labeling experiments were performed for pyrrole synthesis.

A novel and convenient method for the preparation of 5-(diphenylmethylene)-1H-pyrrol-2(5H)-ones; synthesis and mechanistic study

An efficient, regioselective synthesis has been developed for the preparation of 5-(diphenylmethylene)-1H-pyrrol-2(5H)-ones from readily available 1H-pyrroles by sequential dibromination and selective organometallic bromine/lithium exchange followed by reaction with benzophenone. Comparison of various N-substituents was shown to demonstrate the high tolerance of the transformation to functional groups. The structures of the new products were determined by spectroscopic methods and confirmed by single-crystal X-ray diffraction measurement. In addition, theoretical study of the reaction mechanism and selective functionalization of the endocyclic double bond were also presented.

Nano sulfated titania as a heterogeneous solid acid catalyst for the synthesis of pyrroles by clauson-kaas condensation under solvent-free conditions

A new and environmentally benign method for the preparation of N-substituted pyrroles from one-pot condensation reaction of 2,5-dimethoxytetrahydrofuran with amines and diamines in the presence of nano sulfated titania under solvent-free conditions is presented. This new protocol features simple operation, easy availability, stability, and eco-friendliness of catalyst, as well as high to excellent yields of products. In addition, we report for the first time an alternative method for the synthesis of pyrroles from aromatic amines containing the β-lactam fragment using nano sulfated titania as catalyst.

Organometallic approach to the functionalization of alkyl groups containing 1-phenylpyrroles

Novel regioselective methods have been developed for the mono- and difunctionalization of alkyl groups containing 1-phenylpyrroles using different organometallic reagents. Tailoring the reagents and conditions allowed us to prepare several new mono- and r