299426-84-9

Basic information

• Product Name: 1-(2-ETHYL-PHENYL)-1H-PYRROLE
• Synonyms: 1-(2-ETHYL-PHENYL)-1H-PYRROLE
• CAS NO: 299426-84-9
• Molecular Formula: C₁₂H₁₃N
• Molecular Weight: 171.24
• Mol File: 299426-84-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-ETHYL-PHENYL)-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-ETHYL-PHENYL)-1H-PYRROLE(299426-84-9)
• EPA Substance Registry System: 1-(2-ETHYL-PHENYL)-1H-PYRROLE(299426-84-9)

Safety Data

• Hazardous Substances Data: 299426-84-9(Hazardous Substances Data)

Usage

General Description

1-(2-ethyl-phenyl)-1H-pyrrole, also known as 2-ethyl-phenylpyrrole, is a chemical compound with the molecular formula C13H15N. It is a derivative of pyrrole, a five-membered heterocyclic compound containing a nitrogen atom in the ring. 1-(2-ETHYL-PHENYL)-1H-PYRROLE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has also been studied for its potential biological activities, including its use as an antifungal agent and in the treatment of neurodegenerative diseases. 1-(2-ethyl-phenyl)-1H-pyrrole is a valuable component in the development of new drugs and materials, making it a significant molecule in the field of organic chemistry.

Upstream product

• 6117-80-2 1,4-butenediol 
• 578-54-1 ortho-ethylaniline 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 

Relevant articles and documents

Nickel-Catalyzed Synthesis of N-Substituted Pyrroles Using Diols with Aryl- and Alkylamines

Herein, nickel-catalyzed sustainable strategy for the synthesis of N-substituted pyrroles using butene-1,4-diols and butyne-1,4-diols with a series of aryl-, alkyl-, and heteroarylamines is reported. The catalytic protocol is tolerant of free alcohol, halide, alkyl, alkoxy, oxygen heterocycles, activated benzyl, and the pyridine moiety and resulted in up to 90% yield. Initial mechanistic studies involving defined nickel catalyst, determination of rate, and order of reaction including deuterium-labeling experiments were performed for pyrrole synthesis.

Nano sulfated titania as a heterogeneous solid acid catalyst for the synthesis of pyrroles by clauson-kaas condensation under solvent-free conditions

A new and environmentally benign method for the preparation of N-substituted pyrroles from one-pot condensation reaction of 2,5-dimethoxytetrahydrofuran with amines and diamines in the presence of nano sulfated titania under solvent-free conditions is presented. This new protocol features simple operation, easy availability, stability, and eco-friendliness of catalyst, as well as high to excellent yields of products. In addition, we report for the first time an alternative method for the synthesis of pyrroles from aromatic amines containing the β-lactam fragment using nano sulfated titania as catalyst.