299434-10-9Relevant articles and documents
Synthesis of New Diols Derived from Dianhydrohexitols Ethers under Microwave-Assisted Phase Transfer Catalysis
Chatti, Saber,Bortolussi, Michel,Loupy, André
, p. 5877 - 5883 (2007/10/03)
Alkylation of mono-benzylated isosorbide and isomannide was performed under microwave assisted phase transfer catalysis (PTC). A small amount of solvent was necessary to provide good yields (90-96%) within 15 min. In order to minimize the competitive elimination, halide leaving group was changed to tosylate as competitive S(N)2-E2 processes were involved. After removal of benzyl moiety by hydrogenation, a series of new diols from dianhydrohexitols were thus prepared. (C) 2000 Elsevier Science Ltd.