29945-63-9

Upstream product

• 29945-61-7 2-(o-Methoxyphenylthio)-2-phenylacetophenon 
• 79421-99-1 tris(3-methoxyphenyl)-1,3,5,2,4,6-trioxatriborinane 
• 501-65-5 diphenyl acetylene 
• 1484-50-0 desyl bromide 
• 7217-59-6 2-Methoxybenzenethiol 

Downstream Products

• 29938-01-0 2,3-diphenyl-benzo[b]thiophen-7-ol 
• 492471-09-7 1-(7-hydroxy-2,3-diphenyl-benzo[b]thiophen-6-yl)-ethanone 

Relevant academic research and scientific papers

Synthesis of Benzo[b]thiophenes through Rhodium-Catalyzed Three-Component Reaction using Elemental Sulfur

A benzo[b]thiophene synthesis by Rh-catalyzed three-component coupling reaction of arylboronic acids, alkynes, and elemental sulfur (S8) is developed. A notable feature of this protocol is that the thienannulation (thiophene annulation) proceeds with high regioselectivity via the sequential alkyne insertion, C?H activation, and then sulfur atom transfer to the metallacycle intermediate. In a similar manner, dibenzothiophenes can be synthesized from the parent biarylboronic acids and S8. (Figure presented.).

A facile synthesis of 7,8-di aryl coumarino and flavano benzo-thiophenes

The key step for the synthesis of 7-hydroxy 2,3-diarylsubstituted benzothiophenes 5a-f, by starting from substituted 2-aryl-2-((2-methoxy phenyl)thio)acetophenones 3a-f as an intermediate, consists of a Friedel-Crafts cyclization followed by demethylation by Lewis acids like BF3OEt2 and AlCl3 in DCM.