29955-57-5

Upstream product

• 39193-06-1 4,4'-dichlorobenzanilide 
• 122-01-0 4-chloro-benzoyl chloride 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 84900-96-9 2-(4-Chloro-phenyl)-5,7-diphenyl-[1,3,4]thiadiazolo[3,2-a]pyridin-4-ylium; chloride 
• 106-47-8 4-chloro-aniline 
• 23938-13-8 N-p-Chlor-phenyl-p-chlorbenzimidoyl-isothiocyanat 
• 35204-91-2 1-(4-chlorophenyl)pent-4-en-1-one 
• 1073487-01-0 2,3-(4-chlorophenyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one 
• 59134-72-4 2,3-di-(4-chlorophenyl)-quinazoline-4(3H)-one 
• 666175-11-7 1-[(4-chlorophenyl)-(4-chlorophenylimino)methyl]-3-ethylthiourea 
• 666175-04-8 1-[(4-chlorophenyl)-(4-chlorophenylimino)methyl]-3-methylthiourea 

Relevant academic research and scientific papers

Proton-Transfer Polymerization by N-Heterocyclic Carbenes: Monomer and Catalyst Scopes and Mechanism for Converting Dimethacrylates into Unsaturated Polyesters

This contribution presents a full account of experimental and theoretical/computational investigations into the N-heterocyclic carbene (NHC)-catalyzed proton-transfer polymerization (HTP) that converts common dimethacrylates (DMAs) containing no protic gr

Palladium-catalyzed cyclocarbonylation of o-lodoanilines with Imidoyl Chlorides to produce quinazolin-4(3H)-ones

A wide variety of substituted quinazolin-4(3H)-ones were prepared in 63-91% yields by the palladium-catalyzed cyclocarbonylation of o-iodoanilines with imidoyl chlorides and carbon monoxide. The reaction is believed to proceed via in situ formation of an amidine, followed by oxidative addition, CO insertion, and intramolecular cyclization to give the substituted quinazolin-4(3H)-ones.

Synthesis and Biological Evaluation of 2,3,5-Substituted [1,2,4]Thiadiazoles as Allosteric Modulators of Adenosine Receptors

A number of 2,3,5-substituted [1,2,4]thiadiazole analogues of SCH-202676 (N-(2,3-diphenyl-[1,2,4]thiadiazole-5(2H)-ylidene)methanamine, 7a) were synthesized and tested as potential allosteric modulators of adenosine receptors. All compounds were capable of displacing the binding of the radiolabeled agonist [3H]CCPA to human A1 adenosine receptors, whereas modest and varying effects were observed on the binding of [3H]DPCPX, a radiolabeled antagonist for this receptor subtype. Four compounds, 7a (SCH-202676), 7k (LUF5792), 71 (LUF5794), and 8e (LUF5789), were selected for more detailed characterization. They all proved allosteric inhibitors of agonist binding, with 7k being most potent, whereas their effects on antagonist binding were more ambiguous. Subsequently, experiments were done on human adenosine A2A and A3 receptors. Compounds 7a and 7l displayed peculiar displacement characteristics of both radiolabeled agonist and antagonist binding to A2A receptors, whereas 7a showed some activity on A3 receptors.

TETRAZOLES. XXVIII PREPARATION AND PROPERTIES OF 2,3-DIPHENYL-5-ALKYLTETRAZOLIUM SALTS

The oxidation of 1,5-diphenyl-3-alkylformazanes by potassium permanganate in methylene chloride (chloroform)-water two-phase systems is a convenient method for the preparation of 2,3-diphenyl-5-alkyltetrazolium salts.The 2,3-diphenyl-5-alkyltetrazolium salts can be used as catalysts for interphase transfer in reactions proceeding in organic solvent-water two-phase systems, with a neutral or acid aqueous phase.The catalytic activity of 2,3-diphenyl-5-alkyltetrazolium salts increases with increase in the length of the alkyl substituent in the 5-position of the tetrazole ring.