29969-56-0

Basic information

• Product Name: ethyl 2-chloroquinoline-6-carboxylate
• CAS NO: 29969-56-0
• Molecular Formula: C₁₂H₁₀ClNO₂
• Molecular Weight: 235.6663
• EINECS: -0
• Mol File: 29969-56-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-chloroquinoline-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-chloroquinoline-6-carboxylate(29969-56-0)
• EPA Substance Registry System: ethyl 2-chloroquinoline-6-carboxylate(29969-56-0)

Safety Data

• Hazardous Substances Data: 29969-56-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-chloroquinoline-6-carboxylate is used as an intermediate in the synthesis of various pharmaceuticals for its potential anti-inflammatory and antitumor properties. It contributes to the development of new drug candidates that can address a range of health conditions by modulating biological pathways and mechanisms associated with inflammation and cancer.
Used in Agrochemical Industry:
In the agrochemical sector, ethyl 2-chloroquinoline-6-carboxylate is employed as an intermediate in the production of agrochemicals. Its chemical structure allows for the creation of compounds that can be used in pest control and crop protection, enhancing agricultural productivity and ensuring food security.
Used in Chemical Production:
Ethyl 2-chloroquinoline-6-carboxylate is utilized as a building block in the synthesis of a variety of chemicals and compounds. Its unique structure and functional groups make it a key component in the development of new materials and substances with diverse applications across different industries, including but not limited to, pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 110443-51-1 1-oxy-quinoline-6-carboxylic acid ethyl ester 
• 73987-38-9 quinoline-6-carboxylic acid ethyl ester 
• 10349-57-2 Quinoline-6-carboxylic acid 

Downstream Products

• 342908-16-1 2-aminoquinoline-6-carboxylic acid ethyl ester 
• 1136480-06-2 2-(2-Methoxy-benzylamino)-quinoline-6-carboxylic acid 2-methoxy-benzylamide 
• 1136480-09-5 2-(2-methoxy-benzylamino)-quinoline-6-carboxylic acid ethyl ester 
• 849996-80-1 2-chloroquinoline-6-carboxylic acid 

Relevant articles and documents

FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1

The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library

An inhibitor of the complex of factor VIIa and tissue factor (fVIIa/TF), 2-substituted-4-amidinophenylpyruvic acid 1a, was structurally modified with the aim of increasing its potency and selectivity. The lead compound 1a was originally found in our factor Xa (fXa) inhibitor library on the basis of structural similarity of the primary binding sites of fVIIa and fXa. The design was based on computational docking studies using the extracted active site of fVIIa. Compound 1j was found to inhibit factor VIIa/TF at nanomolar concentration with improved selectivity versus fXa and thrombin and it preferentially prolonged the clotting time in the TF-dependent extrinsic pathway.

AMIDINOPHENYLPYRUVIC ACID DERIVATIVES

An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII.