342908-16-1

Basic information

• Product Name: 2-AMINO-6-QUINOLINECARBOXYLIC ACID ETHYLESTER
• Synonyms: 2-AMINO-6-QUINOLINECARBOXYLIC ACID ETHYLESTER;ethyl 2-aMinoquinoline-6-carboxylate
• CAS NO: 342908-16-1
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.23588
• Mol File: 342908-16-1.mol

Chemical Properties

• Boiling Point: 385.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.246±0.06 g/cm3(Predicted)
• PKA: 5.75±0.43(Predicted)
• CAS DataBase Reference: 2-AMINO-6-QUINOLINECARBOXYLIC ACID ETHYLESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-QUINOLINECARBOXYLIC ACID ETHYLESTER(342908-16-1)
• EPA Substance Registry System: 2-AMINO-6-QUINOLINECARBOXYLIC ACID ETHYLESTER(342908-16-1)

Safety Data

• Hazardous Substances Data: 342908-16-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
2-Amino-6-quinolinecarboxylic acid ethylester is used as a building block for the synthesis of other organic compounds, playing a crucial role in the development of novel chemical entities.
Used in Pharmaceutical Development:
It is studied for its potential biological activities and pharmacological properties, which may contribute to the development of new drugs and pharmaceuticals, particularly in the area of antibiotics for treating bacterial infections.
Used in the Development of New Antibiotics:
Given its origin as a derivative of a quinolone antibiotic, 2-Amino-6-quinolinecarboxylic acid ethylester may be employed as a starting material in the creation of new antibiotics to combat resistant bacterial strains.

Upstream product

• 108-95-2 phenol 
• 110443-51-1 1-oxy-quinoline-6-carboxylic acid ethyl ester 
• 73987-38-9 quinoline-6-carboxylic acid ethyl ester 
• 10349-57-2 Quinoline-6-carboxylic acid 
• 29969-56-0 2-chloroquinoline-6-carboxylic acid ethyl ester 

Relevant articles and documents

Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library

An inhibitor of the complex of factor VIIa and tissue factor (fVIIa/TF), 2-substituted-4-amidinophenylpyruvic acid 1a, was structurally modified with the aim of increasing its potency and selectivity. The lead compound 1a was originally found in our factor Xa (fXa) inhibitor library on the basis of structural similarity of the primary binding sites of fVIIa and fXa. The design was based on computational docking studies using the extracted active site of fVIIa. Compound 1j was found to inhibit factor VIIa/TF at nanomolar concentration with improved selectivity versus fXa and thrombin and it preferentially prolonged the clotting time in the TF-dependent extrinsic pathway.

AMIDINOPHENYLPYRUVIC ACID DERIVATIVES

An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII.