29973-16-8Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of N'-morpholinomethylurea derivatives with platelet antiaggregant activity
Ribalta,Artus,Salvador,Roma,Vilageliu,Freixes,Bruseghini
, p. 1782 - 1786 (2007/10/02)
In the attempt to prolong and stabilize the known antiaggregant activity of morpholinomethylurea (MMU) derivatives were prepared with carboxylic acids possessing antiaggregant, antiinflammatory or hypolipemic activity. The results of the experiments showed the important anti-aggregant and hypolipemic activity of N-2(p-chlorophenoxy)-isobutyryl-N'-morpholinomethylurea (plafibride, ITA 104). The results obtained seem to indicate that the activity of these new N-acyl-N'-MMU is due initially to the molecule per se although it cannot be totally ruled out that part of the pharmacodynamic effect of the MMU may depend on a prodrug-like behaviour.
Physico-chemical and analytical studies on plafibride
Torres,Ristol,Ribalta
, p. 1786 - 1790 (2007/10/02)
Physico-chemical and analytical studies on N-2-(p-chlorophenoxy)-isobutyryl)-N'-morpholinomethylurea (plafibride, ITA 104) are reported. Besides the usual analytical data, spectral (UV, IR, NMR, MS) and chromatographic (HPLC, TLC) properties are described. As to chemico-analytical procedures, ITA 104 is detectable by titrimetric and spectralphotometric methods and by thin-layer chromatography.
