5542-60-9

Basic information

• Product Name: 2-(4-CHLOROPHENOXY)-2-METHYLPROPANOYL CHLORIDE
• Synonyms: ASISCHEM A27486;2-(4-CHLOROPHENOXY)-2-METHYLPROPIONYL CHLORIDE;2-(4-CHLOROPHENOXY)-2-METHYLPROPANOYL CHLORIDE;AKOS BB-7853;2-(4-CHLOROPHENOXY)-2-METHYLPROPIONYL CHLORIDE: TECH.;propanoyl chloride, 2-(4-chlorophenoxy)-2-methyl-;2-(4-Chlorophenoxy)-2,2-dimethylacetyl chloride
• CAS NO: 5542-60-9
• Molecular Formula: C₁₀H₁₀Cl₂O₂
• Molecular Weight: 233.09
• Mol File: 5542-60-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 120 °C
• Flash Point: 112.489 °C
• Appearance: /
• Density: 1.271 g/cm³
• CAS DataBase Reference: 2-(4-CHLOROPHENOXY)-2-METHYLPROPANOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENOXY)-2-METHYLPROPANOYL CHLORIDE(5542-60-9)
• EPA Substance Registry System: 2-(4-CHLOROPHENOXY)-2-METHYLPROPANOYL CHLORIDE(5542-60-9)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3265
• HazardClass: IRRITANT
• Hazardous Substances Data: 5542-60-9(Hazardous Substances Data)

Usage

General Description

2-(4-CHLOROPHENOXY)-2-METHYLPROPANOYL CHLORIDE is a chemical compound that is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is a chlorinated acyl chloride with the chemical formula C10H11ClO2. 2-(4-CHLOROPHENOXY)-2-METHYLPROPANOYL CHLORIDE is a key intermediate in the production of various pharmaceuticals and is also used in research and development for its versatile reactivity. It is known for its strong acylating properties and is used in the modification of organic molecules. The compound is also used in the production of various herbicides and pesticides.

Upstream product

• 96-36-6 methyl phosphite 
• 111-92-2 dibutylamine 
• 81928-53-2 dimethyl p-chlorophenoxyisobutyrylphosphonate 
• 1193-00-6 sodium 4-chlorophenolate 
• 106-48-9 4-chloro-phenol 
• 882-09-7 Clofibric acid 

Downstream Products

• 56532-11-7 α-(4-chloro-phenoxy)-isobutyric acid propyl ester 
• 146699-50-5 α-(4-chloro-phenoxy)-isobutyric acid dodecyl ester 
• 637-07-0 Clofibrate 
• 5658-61-7 2-(4-chlorophenoxy)-2-methylpropanamide 
• 55162-41-9 2-[4-chlorophenoxy]-2-methylpropionic acid methyl ester 
• 62753-35-9 α-(4-chloro-phenoxy)-isobutyric acid allyl ester 
• 112551-43-6 (+/-)-α-(4-chloro-phenoxy)-isobutyric acid-(1,2t,5c-trimethyl-4-phenyl-[4r]piperidyl ester) 
• 64919-12-6 dihydrotestosterone p-chlorophenoxyisobutyrate 
• 88674-60-6 2-(4-Chloro-phenoxy)-2-methyl-propionic acid (5S,10R,13S,17S)-3-[2-(4-chloro-phenoxy)-2-methyl-propionyloxy]-10,13-dimethyl-2,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester 
• 124188-31-4 tert-butyl 2-(4-chlorophenoxy)-2-methylpropanoate 
• 86452-66-6 2-(4-Chloro-phenoxy)-2-methyl-propionic acid 4-oxo-4-piperidin-1-yl-butyl ester 
• 99779-90-5 (chloro-4 phenoxy)-isobutyrate d'hydroxy-4 N-((tetramethyl-2,2,6,6 piperidinyl)-4)butyramide 
• 98631-91-5 1,2-bis[4-(2-p-chlorophenoxy-2-methylpropionyloxymethyl)-3,5-dioxopiperazin-1-yl]ethane 
• 54504-70-0 Duolip 

Relevant articles and documents

The cisplatin-based Pt(iv)-diclorofibrato multi-action anticancer prodrug exhibits excellent performances also under hypoxic conditions

Multi-action cisplatin-based mono- (1) and di-clofibric acid (2) Pt(iv) "combo" derivatives were synthesized via both traditional and microwave assisted procedures. The two complexes offered very good performances (IC50 values in a nanomolar ra

Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I

Activation of AMPK emerges as a potential therapeutic approach to metabolic diseases. AdipoRon is claimed to be an adiponectin receptor agonist that activates AMPK through adiponectin receptor 1 (AdipoR1). However, AdipoRon also exhibits moderate inhibition of mitochondrial complex I, leading to increased risk of lactic acidosis. In order to find novel AdipoRon analogues that activate AMPK without inhibition of complex I, 27 analogues of AdipoRon were designed, synthesized and biologically evaluated. As results, benzyloxy arylamide B10 was identified as a potent AMPK activator without inhibition of complex I. B10 dose-dependently improved glucose tolerance in normal mice, and significantly lowered fasting blood glucose level and ameliorated insulin resistance in db/db diabetic mice. More importantly, unlike the pan-AMPK activator MK-8722, B10 did not cause cardiac hypertrophy, probably owing to its selective activation of AMPK in the muscle tissue but not in the heart tissue. Together, B10 represents a novel class of AMPK activators with promising therapeutic potential against metabolic disease.

Acetophenone compounds, preparation methods thereof and application thereof in regulating blood lipid

The invention discloses a compound as shown in formula I or pharmaceutically acceptable salt and a preparation method thereof as well as application thereof in the preparation of drugs for regulatingblood lipid.