29976-76-9

Upstream product

• 29976-72-5 8-bromo-6-methyl-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one 
• 22219-26-7 2'-hydroxy-5'-methylchalkone dibromide 
• 29976-68-9 6-Brom-4-methyl-2-<2.3-dibrom-3-phenyl-propionyl>-phenol 
• 29976-64-5 1-(3-bromo-2-hydroxy-5-methyl-phenyl)-3-phenyl-propenone 
• 194226-50-1 2-hydroxy-3-bromo-5-methyl-α-bromoacetophenone 
• 2538-76-3 1,1'-benzylidenedipiperidine 

Downstream Products

• 29976-90-7 3-(2-hydroxy-3-bromo-5-methylphenyl)-5-phenylisoxazole 
• 140886-00-6 8-bromo-5-methyl-2-phenyl-4H-1-benzopyran-4-thione 
• 140885-86-5 5-(3-bromo-2-hydroxy-5-methylphenyl)-3-phenylisoxazole 
• 140885-95-6 Acetic acid 2-bromo-4-methyl-6-(3-phenyl-isoxazol-5-yl)-phenyl ester 
• 140885-89-8 C₁₈H₁₄BrNO₃ 
• 140885-80-9 8-Bromo-6-methyl-2-phenyl-chromen-4-one oxime 

Relevant academic research and scientific papers

New flavones by a novel synthetic route

Twelve new flavones (3) were prepared by the reaction of 2-hydroxy-α- bromoacetophenones (1) with piperidine or morpholine aminals of benzaldeydes (2) in refluxing methanol. The products (3) were fully characterised by 1H NMR and IR spectroscopy and MS spectrometry.

Oxidation of 2'Hydroxychalcones

2'-Hydroxychalcones (1a-f) or the isomeric flavanones (IIa-f) on refluxing in DMSO for 30 min in the presence of catalytic amount of iodine afford the corresponding flavones (III) in high yields.This method is quicker and appears to be of general applicability.

Reaction of 2'-Hydroxychalcone Dibromides with Me2SO

2'-Hydroxychalcone dibromides on treatment with Me2SO gave 2'-hydroxychalcone, 2'-hydroxy-3'- or 2'-hydroxy-5'-bromochalcone, flavone, monobrominated flavone, 6,8-dibromoflavone, 3-bromoflavone, and 3-, 6-, or 8-dibromoflavone.