29984-41-6 Usage
Uses
Used in Pharmaceutical Industry:
14-O-AcetyldaunoMycinone is used as an active pharmaceutical ingredient for its potent anticancer properties. It is particularly effective against various types of cancer due to its ability to interfere with the synthesis of DNA and RNA, leading to the inhibition of cancer cell growth and proliferation.
Used in Drug Development:
In the field of drug development, 14-O-AcetyldaunoMycinone serves as a key compound for the synthesis of new anticancer drugs. Its unique chemical properties allow researchers to modify and improve its efficacy, potentially leading to the development of more effective and targeted cancer treatments.
Used in Research and Development:
14-O-AcetyldaunoMycinone is also utilized in research and development for studying the mechanisms of action of anticancer drugs. Its role as a metabolite of Daunorubicin provides valuable insights into the pharmacokinetics and pharmacodynamics of this class of drugs, aiding in the design of more effective cancer therapies.
Used in Drug Delivery Systems:
Similar to gallotannin, 14-O-AcetyldaunoMycinone can be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the delivery, efficacy, and targeting of 14-O-AcetyldaunoMycinone can be improved, leading to better treatment outcomes for cancer patients.
Check Digit Verification of cas no
The CAS Registry Mumber 29984-41-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,9,8 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 29984-41:
(7*2)+(6*9)+(5*9)+(4*8)+(3*4)+(2*4)+(1*1)=166
166 % 10 = 6
So 29984-41-6 is a valid CAS Registry Number.
29984-41-6Relevant academic research and scientific papers
Rho, Young S.,Kim, Sun Y.,Kim, Wan-Joong,Yeo, Keun Yun,Hong, Sig Sin,Dong, Jin Yoo
, p. 3497 - 3511 (2004)
The first synthesis of new doxorubicin and daunomycin analogs containing glucuronic acid moieties instead of daunosamine are described. The desired products, daunomycinone-7-D-glucuronide (DM7G, 10) and doxorubicinone-7-D- glucuronide (DX7G, 11) were conveniently prepared through the glycosylation at 7-hydroxyl group of daunomycinone (4) or 14-acetoxydoxorubicinone (6) with glucuronic acid derivative 7 by the Koenigs-Knorr procedure followed by alkaline deacetylatipn using aqueous LiOH solution and amberlite cation exchange material. The anomeric configuration and conformation of all products were fully characterized by assignment of 1H NMR chemical shifts and H-H coupling constants based on reported literatures.
