299916-67-9Relevant articles and documents
Alternative route towards the convergent synthesis of a human purine nucleoside phosphorylase inhibitor-forodesine HCl
Kamath, Vivekanand P.,Xue, Jie,Juarez-Brambila, Jesus J.,Morris Jr., Philip E.
scheme or table, p. 5198 - 5200 (2009/12/06)
Forodesine HCl is being investigated as a potential target for the control of T-cell proliferation. Herein we present an alternative route for the synthesis of the target molecule with addition of lactam to the lithiated deazahypoxanthine (generated in situ). The lactam was synthesized in five steps starting from l-pyroglutamic acid.
Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: Convergent synthesis of the aza-C-nucleoside immucillins
Evans,Furneaux,Hutchison,Kezar,Morris, Jr.,Schramm,Tyler
, p. 5723 - 5730 (2007/10/03)
Means have been developed for the synthesis and addition of 9-deaza-9-lithiopurine derivatives to the carbohydrate-derived cyclic imine 6 in facile convergent syntheses of biologically active aza-C-nucleosides.