299916-89-5Relevant academic research and scientific papers
A novel isoxazole-based scaffold for combinatorial chemistry
Batra,Rastogi,Kundu,Patra,Bhaduri
, p. 5971 - 5974 (2000)
A novel isoxazole-based scaffold has been identified for the generation of combinatorial libraries using solid-phase methods. This scaffold has been utilized to afford high value synthetic intermediates through Baylis-Hillman reaction, Wittig reaction, nitroaldol condensation, and imine and oxime formation. The utility of the scaffold has been demonstrated by synthesizing a small library of 32 isoxazole substituted γ-amino alcohol using four activated alkenes and eight amines. (C) 2000 Elsevier Science Ltd.
