299919-03-2

Upstream product

• 5841-70-3 phenyl(formyl)acetonitrile 
• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 5591-70-8 4-phenyl-1H-pyrazol-3-ylamine 
• 57999-06-1 4-phenyl-1H-pyrazol-5-amine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 7-trifluoromethylpyrazolo[1,5-a]pyrimidines as anti-inflammatory and antimicrobial agents

A series of 2-H/methyl-3-phenyl-5-alkyl/aryl/heteroaryl-7-trifluoromethylpyrazolo[1,5-a]pyrimidines (4a-l) were synthesized by refluxing 3(5)-amino-4-phenyl-5(3)-H/methyl-1H-pyrazoles (1-2) with trifluoromethyl-?2-diketones (3a-f) in ethanol for 6 h. The

Aminoazoles in heterocycles synthesis: II. Trifluoromethyl-containing diketones in the synthesis of pyrazolo[1,5-a]pyrimidines

A regioselective synthesis was carried out of 7-trifluoromethylpyrazolo[1,5-a]pyrimidines by reaction of 3(5)aminopyrazoles with 1,3-diketones containing CF3 group. The characteristic chemical shifts were established for C5 and C7 atoms of the pyrimidine ring and of substituents thereof in the 1H, 13C, and 19F NMR spectra of pyrazolo[1,5-a]pyrimidines.