5591-70-8

Basic information

• Product Name: 4-PHENYL-1H-PYRAZOL-3-YLAMINE
• Synonyms: Pyrazole, 3-amino-4-phenyl-;SMR000309623;ZINC00169443;ZINC04234984;3(or5)-amino-4-phenyl-pyrazol;3-amino-4-phenyl-pyrazol;4-phenyl-1h-pyrazol-4-amin;skf1572
• CAS NO: 5591-70-8
• Molecular Formula: C₉H₉N₃
• Molecular Weight: 159.19
• Mol File: 5591-70-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 170-173℃
• Boiling Point: 394.4 °C at 760 mmHg
• Flash Point: 220.9 °C
• Appearance: /
• Density: 1.238 g/cm³
• Storage Temp.: 2-8°C
• PKA: 15.22±0.50(Predicted)
• CAS DataBase Reference: 4-PHENYL-1H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-1H-PYRAZOL-3-YLAMINE(5591-70-8)
• EPA Substance Registry System: 4-PHENYL-1H-PYRAZOL-3-YLAMINE(5591-70-8)

Safety Data

• Hazard Codes: C,Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 5591-70-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 7, p. 259, 1964 DOI: 10.1021/jm00333a004

Upstream product

• 70515-61-6 (E)-3-(dimethylamino)-2-phenylacrylonitrile 
• 140-69-2 4-methoxybenzylhydrazine 
• 140-29-4 phenylacetonitrile 
• 31881-80-8 (Z)-2-phenyl-3-(p-tolylamino)acrylonitrile 
• 18226-53-4 2-phenyl-3-(piperidin-1-yl)acrylonitrile 
• 1823-91-2 1-phenylethyl cyanide 
• 613-90-1 benzoyl cyanide 
• 70205-70-8 2-dimethylaminomethylene-2-phenylacetonitrile 
• 57488-21-8 (Z)-2-phenyl-3-(piperidin-1-yl)acrylonitrile 
• 5841-70-3 phenyl(formyl)acetonitrile 

Downstream Products

• 1021870-86-9 6-(4-nitrophenyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine 
• 32016-25-4 7-amino-3,6-diphenylpyrazolo<1,5-a>pyrimidine 
• 781641-15-4 1-phenyl-3-(4-phenyl-1H-pyrazol-5-yl)thiourea 
• 1021870-80-3 ethyl 4-amino-8-phenylpyrazolo[5,1-c][1,2,4]triazine-3-carboxylate 
• 1021870-78-9 4-amino-8-phenylpyrazolo[5,1-c][1,2,4]triazine-3-carbonitrile 
• 1021870-82-5 3-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-5,6,8-triamine 
• 1238062-17-3 3-iodo-4-phenyl-1H-pyrazole 
• 941670-54-8 7-amino-3,5-diphenylpyrazolo[1,5-a]pyrimidine-6-carbonitrile 
• 1036646-05-5 6-hydroxy-7-oxo-3-phenyl-1,7-dihydro-pyrazolo[1,5-a]pyrimidine-5-carboxylic acid methyl ester 
• 852470-41-8 4-phenyl-1-(2-piperidin-1-ylethyl)-1H-pyrazol-3-ylamine 
• 130506-88-6 6-acetyl-7-(2-dimethylaminovinyl)-3-phenylpyrazolo<1,5-a>pyrimidine 
• 130506-92-2 6-methyl-3-phenylpyrazolo<1,5-a>pyrido<3,4-e>pyrimidine 
• 99898-77-8 2-methylthio-4-n-butylamino-8-phenylpyrazolo<1,5-a>-s-triazine 
• 99898-79-0 4-n-butylamino-8-phenylpyrazolo<1,5-a>-s-triazine 

Relevant articles and documents

HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to heterocycle substituted amino-pyridine compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Structure and tautomerism of 4-substituted 3(5)-aminopyrazoles in solution and in the solid state: NMR study and Ab initio calculations

Annular tautomerism of 3(5)-aminopyrazoles containing a cyano, thiocyanato, or aryl substituent in the 4-position has been studied by 1H and 13C NMR in solution, cross-polarization and magic-angle spinning 13C NMR in the s

β-Amination of saturated nitriles through palladium-catalyzed dehydrogenation, 1,4-addition, and re-dehydrogenation

Amination at the β-position of 2-arylpropionitriles through catalytic dehydrogenation occurred by using [PdCl2(PMe3) 2] catalyst and bromobenzene. This is the first catalytic reaction involving the direct dehydrogenation of saturated nitriles.