299934-41-1 Usage
Core Structure
Quinazolinone
Function
Potent and selective inhibitor of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)
Mechanism of Action
Inhibits PARP, preventing repair of damaged DNA in cancer cells
Effect
Induces death in cancer cells
Preclinical Studies
Shown promising results in various types of cancer including ovarian, breast, and prostate cancer
Potential Uses
Treatment for various types of cancer
Enhancement of efficacy in combination with chemotherapy
Enhancement of efficacy in combination with radiation therapy
Check Digit Verification of cas no
The CAS Registry Mumber 299934-41-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,9,9,3 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 299934-41:
(8*2)+(7*9)+(6*9)+(5*9)+(4*3)+(3*4)+(2*4)+(1*1)=211
211 % 10 = 1
So 299934-41-1 is a valid CAS Registry Number.
299934-41-1Relevant academic research and scientific papers
QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS
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Page/Page column 13-14, (2011/06/10)
Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as cancers, viral infection and inflammatory diseases or conditions.
