338399-40-9

Upstream product

• 27463-38-3 5-(4-chlorophenyl)cyclohexane-1,3-dione 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 30626-03-0 (3E)-4-(4-chlorophenyl)-3-buten-2-one 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1296687-90-5 7-(4-chloro-phenyl)-1-(4-fluoro-phenylamino)-2,5-dioxo-1,2,5,6,7,8-hexahydro-quinoline-3-carbonitrile 
• 1296687-88-1 7-(4-chloro-phenyl)-2,5-dioxo-1-phenylamino-1,2,5,6,7,8-hexahydro-quinoline-3-carbonitrile 
• 1083066-76-5 2-amino-7-(4-chloro-phenyl)-7,8-dihydro-6H-quinazolin-5-one O-methyl oxime 
• 1083066-72-1 2-amino-7-(4-chloro-phenyl)-7,8-dihydro-6H-quinazolin-5-one oxime 
• 299934-41-1 2-amino-7-(4-chlorophenyl)-7,8-dihydro-5-(6H)-quinazolinone 

Relevant academic research and scientific papers

Tetrahydroquinazoline derivatives and pharmaceutical composition for preventing or treating psoriasis comprising the same

The present invention relates to a tetrahydroquinazoline derivative and a pharmaceutical composition for preventing or treating psoriasis containing the same as an active ingredient. The compound provided in one aspect of the present invention has an effe

QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS

Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as cancers, viral infection and inflammatory diseases or conditions.

Pathways for cyclizations of hydrazine-derived 2-(2-cyanovinyl)-3-oxo- cyclohex-1-ene enolates

The introduction of a hydrazine functionality into 2-(2-cyanovinyl)-3-oxo- cyclohex-1-ene enolates results in their spontaneous cyclizations with participation of the hydrazine moiety. Depending on the reaction conditions used, the hydrazine-derived enola