299952-50-4Relevant academic research and scientific papers
Design and microwave facilitated green synthesis of 2-[4-(3-carboxymethyl, methoxy carbonylmethyl-2,4-dioxo and 4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-2 and 3-methyl propionic acid ethyl ester derivatives: a novel structural class of antidys
Kumar Singh, Ashok,Tripathi, Avinash C.,Tewari, Aseem,Chawla, Viney,Saraf, Shailendra K.
, p. 1535 - 1549 (2017)
An interesting hybrid molecular framework comprising of benzylidenethiazolidin-4-one, chalcone and fibrate was designed and synthesized (BRF1–12) in order to develop safe and efficacious compounds for the treatment of dyslipidemia, and related complicatio
First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness
Smith, Terry K.,Young, Benjamin L.,Denton, Helen,Hughes, David L.,Wagner, Gerd K.
experimental part, p. 1749 - 1752 (2009/12/07)
Drug-like molecules with activity against Trypanosoma brucei are urgently required as potential therapeutics for the treatment of African sleeping sickness. Starting from known inhibitors of other glycosyltransferases, we have developed the first small molecular inhibitors of dolicholphosphate mannose synthase (DPMS), a mannosyltransferase critically involved in glycoconjugate biosynthesis in T. brucei. We show that these DPMS inhibitors prevent the biosynthesis of glycosylphosphatidylinositol (GPI) anchors, and possess trypanocidal activity against live trypanosomes.
