299956-65-3

Upstream product

• 151-50-8 potassium cyanide 
• 299956-63-1 2-{2-[3-(3-bromomethyl-5-methyl-phenyl)-7-chloro-6-nitro-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 199861-72-8 2-{2-[7-chloro-3-(3,5-dimethylphenyl)-6-nitro-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 199861-68-2 7-chloro-3-(3,5-dimethylphenyl)-4-hydroxy-6-nitro-1H-quinolin-2-one 
• 199861-67-1 4-chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-5-nitro-benzoic acid methyl ester 
• 118811-03-3 tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate 
• 78795-16-1 methyl 2-amino-4-chloro-5-nitrobenzoate 
• 119423-95-9 3,5-dimethylphenylacetyl chloride 
• 42288-46-0 (3,5-dimethylphenyl)acetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 

Relevant academic research and scientific papers

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.