299957-29-2

Upstream product

• 147777-32-0 (Z)-5-benzylidenepyrrolidine-2,4-dione 
• 89-98-5 2-chloro-benzaldehyde 
• 299957-25-8 3-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-5-[1-phenyl-meth-(Z)-ylidene]-pyrrolidine-2,4-dione 

Relevant academic research and scientific papers

Grevellin Analogs with Affinity to the N-Methyl-D-aspartate (Glycine Site) Receptor, a Novel Lead Structure

A series of piperidine-2,3,5-triones (azagrevellins) has been prepared. A new synthesis has been introduced using the rearrangement of spiroepoxides in the presence of triethyloxonium tetrafluoroborate. The binding affinity toward the N-methyl-D-aspartate (glycine site) receptor has been measured to provide a basis for more detailed structure-activity studies. Azagrevellin 18d showed the highest binding potency.