147777-32-0Relevant articles and documents
Process for the production of optically-active 4-amino-3-hydroxycarboxylic acids
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, (2008/06/13)
Starting from 5-alkylidene or 5-benzylidenetetramic acid optically-active 4-amino-3-hydroxy-carboxylic acids are produced in the (rel-3R,4R) configuration, especially statine. The synthesis process includes the O-acylation of the tetramic acid to the corr
A Facile Synthesis of N-Protected Statine and Analogues via a Lipase-Catalyzed Kinetic Resolution
Baenziger, Markus,McGarrity, John F.,Meul, Thomas
, p. 4010 - 4012 (2007/10/02)
A new synthesis of N-protected statine 4a and its analogue 4b is presented. cis-(+/-)-Butyric acid 2-isobutyl-5-oxopyrrolidin-3-yl ester (10a) and cis-(+/-)-butyric acid 2-benzyl-5-oxopyrrolidin-3-yl ester (10b) were prepared from methyl (E)-4-chloro-3-me