30003-07-7Relevant academic research and scientific papers
Effects of dansylated acetylcholine analogs on Schistosoma mansoni
Hillman,Chu,Dotson
, p. 516 - 520 (1980)
A series of dansylated fluorescent analogs was synthesized and tested for cholinergic and anticholinergic activity in Schistosoma mansoni. The compounds were compared with a previously reported analog, 5-(dimethylamino)-N-(2-dimethylaminoethyl)naphthalenesulfonamide hydrochloride. All of the compounds produced some fluorescent labeling of a structure in the head region of the worms. Major differences were not seen among the compounds. The compounds were also tested as antagonists of carbachol-induced paralysis in an activity monitor. Significant carbachol antagonism was seen for all compounds. Effects on the serotonin response were also recorded. Only one compound, a dibutylaminopropylamine derivative, produced striking antagonism of serotonin-induced motor activity.
Binding of dansylamide 1 derivatives to nucleotides and nucleic acids
Wang, Xuemei,Schneider, Hans-Joerg
, p. 1323 - 1328 (1998)
Dansylamide ? has been modified by the introduction of several side chains into the sulfonamide substituent. Compounds with no, or with only one positive charge at the side chains were found not to be useful for association studies with nucleotides or nucleic acids. Relatively high binding constants with moderate base selectivities have been observed with a ligand obtained from dansyl chloride and N,N′-bis(3-aminopropyl)piperazine, which contains two dansyl units and two permanently charged peralkylammonium centers. Interactions of this ligand with double-stranded nucleic acids show a biphasic binding, the first at base pair concentrations below 10-7 M being only detectable by a decrease of fluorescence intensity. The second phase is characterized by increased fluorescence and by wavelength changes similar to effects observed in lipophilic solvents and by affinities of up to 5 × 105 M. At higher concentrations bathochromic shifts and extinction changes in UV spectra of the dye suggest an intercalation mechanism, in line with preliminary circular dichroism studies.
Combined photophysical, NMR and theoretical (DFT) study on the interaction of a multi component system in the absence and presence of different biologically and environmentally important ions
Bhoi, Abhas Kumar,Sahu, Prabhat Kumar,Jha, Gaurav,Sarkar, Moloy
, p. 61258 - 61269 (2015)
A simple multi-component system, comprising fluorophore (dansylamide), spacer (propyl) and receptor (dimethylamino) units, has been synthesized in order to investigate the receptor-analyte binding interactions in the presence of both cations and anions within a single molecular system. While the acidic N-H proton of the dansylamide group is expected to interact with a basic anion, the dimethylamino group is expected to interact with metal ions. The photophysical behaviour of this system in the absence and presence of various metal ions and anions is investigated in acetonitrile (ACN) medium. The absorption and fluorescence spectra of the system in ACN consist of broad bands, typical of the intramolecular charge transfer (ICT) nature of the system. A significant reduction in the fluorescence intensity of the system in the presence of fluoride has been observed. No significant changes in the optical properties of the system have been noticed in the presence of other commonly encountered anions. The interaction of fluoride with the present system has also been monitored through 1H NMR experiments. The formation of the HF2- species due to the abstraction of the acidic proton by F- is believed to be responsible for the fluoride ion selective signalling behaviour. In the case of cations, a bathochromic shift in fluorescence, as well as a concomitant decrease in fluorescence intensity, of the present system has been observed in the presence of transition metal ions. Interestingly, no bathochromic shifts in absorbance or fluorescence, were observed when a similar experiment was carried out employing a structurally similar compound which is devoid of the dimethylamino group. The cation signalling event has also been monitored through FTIR and 1H NMR experiments. Spectroscopic results indicate a ground state 1: 2 complex formation between the present system and the transition metal ions. Theoretical calculations have also been carried out in the presence of various analytes to throw more light on the binding interactions. Additionally, through fluorescence microscopy studies, it has been observed that the present system is non-toxic in a cellular environment, and has the potential to be used in live-cell imaging studies.
Synthesis, structures and properties of self-assembling quaternary ammonium dansyl fluorescent tags for porous and non-porous surfaces
Porosa, Lukasz M.,Mistry, Kamlesh B.,Mocella, Amanda,Deng, Hellen,Hamzehi, Shayan,Caschera, Alex,Lough, Alan J.,Wolfaardt, Gideon,Foucher, Daniel A.
, p. 1509 - 1520 (2014/03/21)
A series of H2O and/or EtOH soluble, self-assembling quaternary ammonium salts containing a dansyl (DNS) fluorescent moiety suitable for attachment to both porous ([DNS-NH-(CH2)3-NMe 2-R+][X-/su
PHOSPHORUS FUNCTIONAL ANTIMICROBIAL COATINGS FOR METAL SURFACES
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Page/Page column 70; 71, (2014/09/03)
The invention relates to quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds, processes for preparing quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds, antimicrobial coating compositions comprising quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds and method of treating a surface with said compositions to provide a durable, antimicrobial-treated surface.
