30005-32-4

Usage

General Description

2-({[1-(2-thienyl)ethylidene]amino}oxy)acetic acid is a chemical compound with the molecular formula C10H11NO4S. It is a derivative of thienyl and is used as an intermediate in organic synthesis. The compound contains a thiophene ring, which is a sulfur-containing aromatic ring, and an amino group attached to an acetic acid group. It can be used as a building block in the synthesis of pharmaceuticals and other organic compounds. 2-({[1-(2-THIENYL)ETHYLIDENE]AMINO}OXY)ACETIC ACID is also used in research and development in the pharmaceutical and chemical industries.

Upstream product

• 79-11-8 chloroacetic acid 
• 1956-45-2 2-acetylthiophene oxime 

Relevant academic research and scientific papers

Study of the Room-Temperature Synthesis of Oxime Ethers by using a Super Base

In this study, we present a convenient method for the synthesis of oxime ethers by reacting oximes with various chlorides (alkyl, functionalized alkyl, and benzyl) and with the subsequent use of a super base—pulverized potassium hydroxide in DMSO. The reactions take place at room temperature and the products are obtained in high yields. The final products were received within 2 min to 3 h. In addition, the compounds do not require chromatographic separation. The structure elucidation of the titled compounds was performed by using 1H NMR and 13C NMR spectroscopy as well as mass spectrometry. The presented method of synthesis for oxime ethers is environmentally friendly, because neither water cooling or heating of the reaction mixture/solvents (necessary for chromatographic purification) is required. The synthesis can be carried out very easily on a large scale.