1956-45-2

Basic information

• Product Name: 1-THIOPHEN-2-YL-ETHANONE OXIME
• Synonyms: 1-(THIEN-2YL)ETHAN-1-ONE OXIME;1-THIOPHEN-2-YL-ETHANONE OXIME;1-(2-THIENYL)-ETHAN-1-ONE OXIME;AURORA 15194;1-(2-thienyl)ethanone oxime;2-[1-(Hydroxyimino)ethyl]thiophene;Methyl 2-thienyl ketone oxime;Methyl(2-thienyl) ketoneoxime
• CAS NO: 1956-45-2
• Molecular Formula: C₆H₇NOS
• Molecular Weight: 141.19
• EINECS: 217-800-2
• Mol File: 1956-45-2.mol
• Article Data: 41

Chemical Properties

• Melting Point: 113 °C
• Boiling Point: 258.1°Cat760mmHg
• Flash Point: 109.9°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 0.00715mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 1-THIOPHEN-2-YL-ETHANONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 1-THIOPHEN-2-YL-ETHANONE OXIME(1956-45-2)
• EPA Substance Registry System: 1-THIOPHEN-2-YL-ETHANONE OXIME(1956-45-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1956-45-2(Hazardous Substances Data)

Usage

General Description

1-THIOPHEN-2-YL-ETHANONE OXIME, also known as thioacetophenone oxime, is a chemical compound with the molecular formula C8H9NOS. It is a pale yellow liquid with a pungent odor, and it is commonly used as a reagent in organic chemistry. 1-THIOPHEN-2-YL-ETHANONE OXIME is often utilized in the preparation of various derivatives and as a building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, 1-THIOPHEN-2-YL-ETHANONE OXIME has been studied for its potential biological activities, including antiproliferative and antimicrobial properties. However, it is important to handle this chemical with care as it can be toxic and irritating to the skin, eyes, and respiratory system.

InChI:InChI=1/C6H7NOS/c1-5(7-8)6-3-2-4-9-6/h2-4,8H,1H3/b7-5-

Upstream product

• 88-15-3 2-Acetylthiophene 
• 71-23-8 propan-1-ol 
• 543-67-9 n-propyl nitrite 
• 541-42-4 i-propyl nitrite 
• 67-63-0 isopropyl alcohol 
• 546-88-3 acetylhydroxamic acid 
• 3051-27-2 1-(2-thienyl)-1,3-butanedione 

Downstream Products

• 6309-16-6 1-thiophen-2-yl-ethylamine 
• 6007-78-9 thiophene-2-carbonyl cyanide 
• 52707-46-7 2-(thiophen-2-yl)-1H-pyrrole 
• 64663-51-0 1-vinyl-2-(2-thienyl)pyrrole 
• 93755-08-9 (Z)-2-acetylthiophene O-vinyloxime 
• 93755-07-8 (E)-2-acetylthiophene O-vinyloxime 
• 88-15-3 2-Acetylthiophene 
• 13053-81-1 2-acetylaminothiophene 
• 159110-45-9 (E)-Methyl 2-thienyl ketone O-propargyloxime 
• 1246854-96-5 (E)-1-(2-furyl)-3-phenyl-3-({[(E)-1-(2-thienyl)ethylidene]amino}oxy)-2-propen-1-one 
• 113982-68-6 3,3-diphenyl-N-(1-(thiophen-2-yl)ethyl)propanamide 
• 113982-69-7 3,3-diphenyl-N-(1-(thiophen-2-yl)ethyl)propan-1-amine 
• 1246854-95-4 (E)-1,3-diphenyl-3-({[(E)-1-(2-thienyl)ethylidene]amino}oxy)-2-propen-1-one 
• 1246854-97-6 (E)-1-(2-thienyl)-3-phenyl-3-({[(E)-1-(2-thienyl)ethylidene]amino}oxy)-2-propen-1-one 

Relevant articles and documents

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Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides

Disclosed herein is an efficient Ag-catalyzed [4 + 1] heteroannulation reaction of enamides with α-carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant tetra-substituted oxazolines is further demonstrated by a series of useful manipulations into valuable building blocks of pharmaceutical relevance.

Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters

Polysubstituted indoles are prevalent in pharmaceuticals, agrochemicals, and organic materials. Presented herein is the fact that polyfunctionalized indoles can be efficiently constructed from easily accessible oxime esters and aryl iodides, involving a palladium/norbornene synergistic synthesis. The reaction is enabled by a unique class of electrophiles in palladium/norbornene cooperative catalysis, which are oxime esters derived from simple ketone. The broad substrate scope and high functional group tolerance could make this method attractive for the synthesis of polysubstituted indoles.