30006-28-1Relevant academic research and scientific papers
Hydrolysis of 2,4-dithiophenobarbital
Tarsa, Monika,Zuchowski, Grzegorz,Stasiewicz-Urban, Anna,Bojarski, Jacek
experimental part, p. 123 - 128 (2009/06/20)
Hydrolysis of 2,4-dithiophenobarbital in aqueous solutions of pH 2 - 12 was investigated at 40 and 60°C using UV spectrophotometry. The values of reaction order, rate constants, pKal and pKa2 and activation energy were determined. The preliminary estimation of degradation products was accomplished using thin layer chromatography. The major products were isolated by circular chromatography and identified by spectroscopic and classical methods.
Synthesis of thio derivatives of phenobarbital and its N-methyl derivatives
Stasiewicz-Urban,Kubaszek,Zylewski,Cegla,Bojarski
, p. 2105 - 2115 (2007/10/03)
Differently substituted thio derivatives of phenobarbital and its N-mono- and N,N′-dimethyl derivatives were obtained by thionation of respective substrates with Lawesson's reagent. The structure of the products not described in the literature was confirmed by spectral and elemental analyses. The spectral properties allow to differentiate between positional isomers of the products.
