1636-25-5

Usage

Uses

Used in Pharmaceutical Industry:
Ethylphenylmalonic acid is used as a key intermediate for the synthesis of various pharmaceuticals due to its chemical reactivity and stability. It plays a crucial role in the production of a wide range of pharmaceuticals, contributing to the development of new drugs and improving existing ones.
Used in Organic Synthesis:
Ethylphenylmalonic acid is used as a versatile intermediate in organic synthesis for the creation of various organic compounds. Its carboxylic acid functional group allows for a wide range of chemical reactions, making it an essential component in the synthesis of diverse organic molecules.

InChI:InChI=1/C11H12O4/c1-2-11(9(12)13,10(14)15)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H,12,13)(H,14,15)

Upstream product

• 30006-28-1 2,4-dithiophenobarbital 
• 75-03-6 ethyl iodide 
• 76-67-5 diethyl ethyl(phenyl)malonate 
• 115-38-8 mephobarbital 
• 50-06-6 phenobarbital 
• 2613-89-0 phenylmalonic acid 

Downstream Products

• 54095-15-7 2-ethyl-2-phenylmalonyldichloride 
• 108953-96-4 5-ethyl-2,2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione 
• 20452-67-9 phenylethylketene 
• 1550-86-3 Aethyl-phenyl-malonyl-bis-trifluoracetat 
• 108516-37-6 monomethyl ethylphenylmalonate 
• 88253-95-6 dimethyl 2-ethyl-2-phenylmalonate 
• 2294-71-5 methyl 2-phenylbutanoate 
• 177532-27-3 (S)-(-)-2-hydroxymethyl-2-phenylbutyric acid 
• 17575-59-6 glutethimide 
• 177532-28-4 methyl (R)-(+)-2-formyl-2-phenylbut-3-enoate 
• 170450-73-4 (S)-(+)-2-ethyl-2-phenylglutaric acid 
• 177532-26-2 (S)-(+)-5-ethyl 1-methyl 2-ethyl-2-phenylglutarate 
• 177532-29-5 (S)-(+)-4-ethyl-4-phenylpent-2-enedioic acid 1-ethyl ester 5-methyl ester 
• 177532-30-8 (S)-2-Methoxycarbonyloxycarbonyl-2-phenyl-butyric acid methyl ester 

Relevant academic research and scientific papers

Hydrolysis of 2,4-dithiophenobarbital

Hydrolysis of 2,4-dithiophenobarbital in aqueous solutions of pH 2 - 12 was investigated at 40 and 60°C using UV spectrophotometry. The values of reaction order, rate constants, pKal and pKa2 and activation energy were determined. The preliminary estimation of degradation products was accomplished using thin layer chromatography. The major products were isolated by circular chromatography and identified by spectroscopic and classical methods.

Asymmetric construction of benzylic quaternary carbons from chiral malonates: Formal synthesis of both (-)- and (+)-aminoglutethimides AG and analogues

From a single chiron (R)-(+)-5, available with high enantiomeric excess (97%) by enzymatic hydrolysis (PLE acetonic powder) of a malonate, were prepared convenient precursors of aminoglutethimides (-)-AG-1 and (+)-AG-1. This versatile method also allows preparation of the b-hydroxy ester (R)-9 and its enantiomer (S)-9 as well as the glutethimides (S)-4 and (R)-4 and other analogues.

N-Alkyl barbiturates. A series of compounds for the study of metabolic structure-activity relationships

Many therapeutic agents are metabolised along multiple pathways, but up to now there have been few investigations addressing the question of which chemical features of drugs govern the participation in, and quantitative significance of, different biotransformation pathways. To assess the influence of variations of the chemical structure upon metabolim, a series of novel barbiturate analogues has been synthesized. The N1-monoalkylated and N1,N2-dialkylated phenobarbitones and 2-desoxyphenobarbitones have been synthesized via condensation of ethylphenylmalonic acid derivatives with different N-alkylated ureas or thioureas, and/or by base-catalyzed N-alkylation of different barbituric acids.