30020-98-5

Basic information

• Product Name: 1H-Indole, 1-methyl-3-phenyl-
• CAS NO: 30020-98-5
• Molecular Formula: C15H13N
• Molecular Weight: 207.275
• Mol File: 30020-98-5.mol
• Article Data: 65

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-methyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-methyl-3-phenyl-(30020-98-5)
• EPA Substance Registry System: 1H-Indole, 1-methyl-3-phenyl-(30020-98-5)

Safety Data

• Hazardous Substances Data: 30020-98-5(Hazardous Substances Data)

Usage

Derivative of indole

A heterocyclic aromatic compound commonly found in many natural products and pharmaceuticals

Physical state at room temperature

White to off-white solid

Solubility

Insoluble in water

Uses

Building block and intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes

Pharmacological activities

Potential activities studied for the treatment of various diseases including cancer and neurological disorders.

Upstream product

• 32119-53-2 N-methyl-N-phenacylaniline 
• 2739-12-0 N-methylaniline hydrochloride 
• 532-27-4 1-chloroacetophenone 
• 100-61-8 N-methylaniline 
• 1504-16-1 3-phenyl-1H-indole 
• 74-88-4 methyl iodide 
• 17583-40-3 2-methylaminobenzonitrile 
• 75-57-0 tetramethlyammonium chloride 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 615-36-1 2-bromoaniline 
• 603-76-9 1-methylindole 
• 108-94-1 cyclohexanone 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 1859-76-3 2-(methylamino)benzophenone 

Downstream Products

• 3558-24-5 1-methyl-2-phenyl-1H-indole 
• 1196785-95-1 2-(3-methoxyphenyl)-1-methyl-3-phenylindole 
• 1290629-00-3 N-(2-chlorophenyl)-1-methyl-3-phenyl-1H-indol-2-amine 
• 1290629-05-8 5-methyl-10b-phenyl-5,10b-dihydroindolo[2,3-b]indole 
• 1290629-10-5 3-(2-aminophenyl)-1-methyl-3-phenyl1H-indolin-2-one 
• 54470-43-8 2-bromo-1-methyl-3-phenyl-1H-indole 
• 1402063-86-8 ethyl 2-hydroxy-2-(1-methyl-3-phenyl-1H-indol-2-yl)acetate 
• 321854-38-0 1-methyl-3-phenyl-1H-indole-2-carbaldehyde 
• 1198116-22-1 7-methyl-5,6-diphenyl-7H-benzo[c]carbazole 
• 1360059-25-1 N-(4-chlorophenyl)-4-methyl-N-(1-methyl-1H-indol-2-yl)benzenesulfonamide 

Relevant articles and documents

Regioselective 2-alkylation of indoles with α-bromo esters catalyzed by Pd/P,P=O system

A palladium-catalyzed 2-alkylation of indoles with α-bromo esters is developed by employing a P,P=O ligand. The method features excellent regioselectivities, mild reaction conditions, and good functional group compatibility. The employment of the P,P=O ligand as well as 4? molecular sieves were crucial for the success of the transformation. Mechanistic studies indicate the reaction proceed through a radical pathway.

C3-Arylation of indoles with aryl ketonesviaC-C/C-H activations

C3-Arylation of indoles with aryl ketones is accomplishedviapalladium-catalyzed ligand-promoted Ar-C(O) cleavage and subsequent C-H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good yields. Further introduction of an indole moiety into the natural products desoxyestrone and evodiamine demonstrate the synthetic utility of this protocol.

Metal and Oxidant Free Construction of Substituted- and/or Polycyclic Indoles: A Useful Alternative to Bischler and Related Syntheses

A wide range of substituted indoles or polycyclic derivatives containing the indole core are easily accessible by acidic treatment of aromatic amines and 1,2-diaza-1,3-dienes. Unlike the related indole-Bischler synthesis, the regioselectivity of the method here reported is unique and predictable, the yields are generally good and also electron withdrawing substituted indoles are smoothly recovered.