300374-83-8

Usage

Uses

Used in Pharmaceutical Industry:
3',4'-DIMETHOXY-2,2,2-TRIFLUOROACETOPHENONE is used as a precursor in the synthesis of various drugs, contributing to the development of new medications for different health conditions.
Used in Agrochemical Industry:
3',4'-DIMETHOXY-2,2,2-TRIFLUOROACETOPHENONE is used as a starting material for the production of pesticides, helping to create effective solutions for pest control in agriculture.
Used in Flavor and Fragrance Industry:
3',4'-DIMETHOXY-2,2,2-TRIFLUOROACETOPHENONE is used in the synthesis of flavoring agents and fragrances, adding unique scents and tastes to various consumer products.
Safety Precautions:
Due to its potential health and environmental hazards, proper safety precautions and handling procedures should be followed when working with 3',4'-DIMETHOXY-2,2,2-TRIFLUOROACETOPHENONE.

InChI:InChI=1/C10H9F3O3/c1-15-7-4-3-6(5-8(7)16-2)9(14)10(11,12)13/h3-5H,1-2H3

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 75-46-7 trifluoromethan 
• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 131252-26-1 1-(3,4-dimetoksyfenylo)-2,2,2-trifluoroetan-1-ol 

Downstream Products

• 1422985-05-4 (E)-1,2-dimethoxy-4-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene 
• 1422985-24-7 3-(2-(3,4-dimethoxyphenyl)-1,1,1-trifluoro-3-nitropropan-2-yl)-1H-indole 
• 1422984-85-7 C₁₁H₁₂F₃NO₅ 

Relevant academic research and scientific papers

Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system

A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the potent greenhouse gas fluoroform (HCF3, HFC-23) was developed. The combination of fluoroform and KHMDS in triglyme at ?40 °C was effective for this transformation, with good yields as high as 92%. Substrate scope of the trifluoromethylation procedure was explored for aromatic, aliphatic, and conjugated methyl esters. This study presents a straightforward trifluoromethylation process of various methyl esters that convert well to the corresponding trifluoromethyl ketones. The tolerance of various pharmacophores under the reaction conditions was also explored.

Copper-Mediated Trifluoroacetylation of Arenediazonium Salts with Ethyl Trifluoropyruvate

A copper-mediated trifluoroacetylation of various arenediazonium salts with ethyl trifluoropyruvate is reported. The reaction proceeded smoothly under mild conditions at room temperature giving trifluoromethyl aryl ketones in moderate to good yields. A variety of functional groups, including methoxy, hydroxy, ester, ketone, trifluoromethyl, and halide groups, were well tolerated. A possible reaction mechanism involving an aryl radical intermediate was proposed and supported by experimental evidence. This reaction provides a new route to trifluoromethyl aryl ketones, notable synthetic targets, from the corresponding anilines.

NHC-Copper(I) Halide-Catalyzed Direct Alkynylation of Trifluoromethyl Ketones on Water

An efficient and easily scalable NHC-copper(I) halide-catalyzed addition of terminal alkynes to 1,1,1-trifluoromethyl ketones, carried out on water for the first time, is reported. A series of addition reactions were performed with as little as 0.1-2.0?mo

Mixed-Metal MIL-100(Sc,M) (M=Al, Cr, Fe) for Lewis acid catalysis and tandem C-C Bond formation and alcohol oxidation

The trivalent metal cations Al3+, Cr3+, and Fe3+ were each introduced, together with Sc3+, into MIL- 100(Sc,M) solid solutions (M=Al, Cr, Fe) by direct synthesis. The substitution has been confirmed by powder X-

Oxime derivatives and the use thereof as latent acids

Compounds of formula I, II and III, wherein wherein R1is for example hydrogen, C1-C12alkyl, C3-C30cycloalkyl, C2-C12alkenyl, C4-C8cycloalkenyl, phenyl, whic