300398-28-1Relevant articles and documents
Preparation of 1,2-substituted benzimidazolesviaa copper-catalyzed three component coupling reaction
Yang, Weiguang,Zhao, Yu,Zhou, Zitong,Li, Li,Cui, Liao,Luo, Hui
, p. 8701 - 8707 (2021/03/06)
1,2-Substituted benzimidazoles were prepared by simply stirring a mixture of copper catalysts,N-substitutedo-phenylenediamines, sulfonyl azides and terminal alkynes. Particularly, the intermediateN-sulfonylketenimine occurred with two nucleophilic addition and the sulfonyl group was eliminatedviacyclization. In a way, sulfonyl azides and copper catalysts activated the terminal alkynes to synthesize benzimidazoles.
Iridium(III)-Catalyzed One-Pot Access to 1,2-Disubstituted Benzimidazoles Starting from Imidamides and Sulfonyl Azides
Xu, Linhua,Wang, Lianhui,Feng, Yadong,Li, Yudong,Yang, Lei,Cui, Xiuling
supporting information, p. 4343 - 4346 (2017/08/23)
A novel Ir-catalyzed annulation of imidamides with sulfonyl azides has been developed. 1,2-Disubstituted benzimidazoles could be easily obtained in up to 99% yield for more than 40 examples. The products further streamline the synthesis of molecules that are important building blocks for organic synthesis and drug discovery. This strategy features high regioselectivity, efficiency, good tolerance of functional groups, and mild reaction conditions.
Palladium-catalyzed intramolecular sulfonamidation/oxidation of imines: Access to multifunctional benzimidazoles
Fu, Shaomin,Jiang, Huanfeng,Deng, Yuanfu,Zeng, Wei
, p. 2795 - 2804 (2011/12/01)
O-Sulfonamidophenylimines undergo intramolecular sulfonamidation/oxidation to produce 1,2-disubstituted benzimidazoles upon treatment with palladium(II) chloride/(diacetoxyiodo)benzene and potassium carbonate at room temperature. The substituent scope at
